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Photodynamic Therapy by singlet oxygen generation

Photodynamic therapy (PDT) is a non-invasive therapeutic technique against cancer and age-related macular degeneration (AMD), but also as alternative treatment against drug resistant bacteria. PDT requires photosensitizers (PSs) which, upon appropriate irradiation, will generate highly cytotoxic singlet oxygen (1O2), causing cell death of targeted cancer. Our interest is focused toward PSs based on long living-excited state molecular systems such as phosphorescent iridium(III) complexes, the latter displaying intrinsically desirable characteristics: (i) low toxicity; (ii) ability to penetrate cells (cytoplasm and/or organelles); (iii) efficient absorption of light in the visible or even in the transparency window of tissues; (iv) the presence of the heavy atom allows for the quasi-quantitative generation of the triplet state, which is generally associated with high 1O2 generation; and (v) they are photobleaching resistant. 

Dr. Amandine Hurbin, Institut for advanced Sciences (IAB), Grenoble

Publié le 26 septembre 2022

Mis à jour le 12 février 2024