• Bienvenue au DCM


    Le Département de Chimie Moléculaire de Grenoble est une unité mixte de recherche (UMR-5250) associant le CNRS et l’Université Grenoble Alpes. Créé le 01 Janvier 2007 par le regroupement des unités LEDSS (UMR-5616) et LEOPR (UMR-5630), le DCM mobilise environ 150 personnes autour de deux axes de recherches interactifs qui sont la chimie pour la santé et la chimie pour les nanosciences.

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  • BEA

    Biosystèmes Electrochimiques et Analytiques

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  • I2BM

    Ingénierie et Interactions BioMoléculaires

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  • Chimie Inorganique Redox

    CIRE laboratory develops its research in the fields of molecular electrochemistry and redox photochemistry. We design molecular architectures with diverse functionalities often inspired by a bio-mimetic approach. Our work is directed towards both fundamental research(switchable systems, artificial photosynthesis, metal-radical coupling) and practical applications (nano-chemical devices, inhibitors development).

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  • SeRCO

    Synthèse et Réactivité en Chimie Organique

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  • Spectrométrie, Interactions, Chimie Théorique

    Expertise in the field of theoretical chemistry and experimental mass spectrometry :
    At the upper right, study of alkynes activation by Au(I) complexes with the help of Mass spectrometry; At the bottom in the left, TD-DFT development for the photochemistry ; At the bottom in the middle QM/MM Studies of Tyrosinase inhibitors ; At the right modelization of the reactivity in solution 

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Agenda

ZOOM

ZOOM Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry
The direct biolayer interferometry (BLI) measurement of low-molecular-weight (LMW) analytes (<200 Da) still represents a challenge, in particular, when low receptor densities are used. BLI is a powerful optical technique for the label-free, real-time characterization and quantification of biomolecular interactions at interfaces. We demonstrate herein that the quantification of biomolecular recognition is possible by BLI using either 2D-like or 3D platforms for aptamer ligand immobilization. The influence of the aptamer density on the interaction was evaluated and compared for the two sensor architectures. Despite the LMW of the analyte, BLI monitoring led to signals that are exploitable for affinity and kinetic studies, even at low aptamer density. We demonstrate that the immobilization format as well as the aptamer density has a crucial influence on the determination of the recognition parameters.
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