NICOLAS SPINELLI
Professeur des universités
Affiliation
Université Grenoble Alpes
Équipe de recherche
DCM-I2BM
Domaines de recherche
Oligonucleotides, Aptamères, Biocapteurs, Catalyse
Disciplines scientifiques
Chimie organique, minérale, industrielle
Habilitation à diriger des recherches
Conjugaison d’acides nucléiques : application au domaine des aptamères
sous la direction de Pr. Christian Leumann; Dr. Karine Alvarez; Dr. Didier Gasparutto; Dr. Jean-Jacques Vasseur; Pr. Eric Defrancq
from 22/10/2013 to 23/10/2013
sous la direction de Pr. Christian Leumann; Dr. Karine Alvarez; Dr. Didier Gasparutto; Dr. Jean-Jacques Vasseur; Pr. Eric Defrancq
from 22/10/2013 to 23/10/2013
Thèse
Evaluation de protdection non basolabiles pour al synthése supportée de prodrogues d'oligonucléotides. Analyse MALDI-Tof d'oligonucléotides supportés
sous la direction de Dr J.-J Vasseur
from 01/10/1998 to 20/11/2001
sous la direction de Dr J.-J Vasseur
from 01/10/1998 to 20/11/2001
Colas, Y., Ménage S., Marchi-Delapierre C., & Spinelli N.
(2023). Use of constrained G-quadruplexes for enantioselective sulfoxidation site mapping.
ChemCatChem. n/a, e202300914.
Pons, M., Perenon M., Bonnet H., Gillon E., Vallée C., Coche-Guérente L., et al.
(2022). Conformational transition in SPR experiments: impact of spacer length, immobilization mode and aptamer density on signal sign and amplitude.
Analyst. 147, 4197-4205.
Nicolas Spinelli obtained its Ph.D. in bioorganic chemistry in 2001 from University Montpellier II (supervisor Dr. J.-J. Vasseur) on the synthesis of oligonucleotides prodrugs. After his Ph.D., he joined the group of Dr. B. Mandrand (UMR 2714 CNRS/bioMérieux, ENS Lyon) where he worked on the synthesis of oligonucleotides conjugated with pyrrole and ferrocene moieties and their use in electrochemical DNA biosensors. He joined the DCM (Grenoble) in 2005 where he obtained an Assistant Professor position in 2006. His current researches efforts are focused on the synthesis of oligonucleotides conjugates especially for sensors applications. He obtained accreditation to supervise research (HDR) in 2013.
Keywords : Oligonucleotides, Aptamers, Catalysis, Aptasensors
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