NICOLAS SPINELLI
Maître de conférences
Affiliation
Université Grenoble Alpes
Équipe de recherche
DCM-I2BM
Domaines de recherche
Oligonucleotides, Aptamères, Biocapteurs, Catalyse
Disciplines scientifiques
Chimie organique, minérale, industrielle
Habilitation à diriger des recherches
Conjugaison d’acides nucléiques : application au domaine des aptamères
sous la direction de Pr. Christian Leumann; Dr. Karine Alvarez; Dr. Didier Gasparutto; Dr. Jean-Jacques Vasseur; Pr. Eric Defrancq
from 22/10/2013 to 23/10/2013
sous la direction de Pr. Christian Leumann; Dr. Karine Alvarez; Dr. Didier Gasparutto; Dr. Jean-Jacques Vasseur; Pr. Eric Defrancq
from 22/10/2013 to 23/10/2013
Thèse
Evaluation de protdection non basolabiles pour al synthése supportée de prodrogues d'oligonucléotides. Analyse MALDI-Tof d'oligonucléotides supportés
sous la direction de Dr J.-J Vasseur
from 01/10/1998 to 20/11/2001
sous la direction de Dr J.-J Vasseur
from 01/10/1998 to 20/11/2001
Vignon, A., Flaget A., Michelas M., Djeghdir M., Defrancq E., Guerente L., et al.
(2020). Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry.
ACS Sensors. 5(8), 2326 – 2330.
MacDonald, H., Bonnet H., Van der Heyden A., Defrancq E., Spinelli N., Guerente L., et al.
(2019). Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study.
J. Phys. Chem. C. 123, 13561–13568.
Dejeu, J., Bonnet H., Spinelli N., Defrancq E., Guerente L., Van der Heyden A., et al.
(2018). Impact of Conformational Transitions on SPR Signals-Theoretical Treatment and Application in Small Analytes/Aptamer Recognition..
J. Phys. Chem. C. 122, 21521–21530.
Saint-Germes, L., Bar L., Dejeu J., Spinelli N., Defrancq E., & Pratviel G..
(2017). The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH..
Dalt. Trans.. 46, 12088–12094.
Haddache, F., Le Goff A., Spinelli N., Gairola P., Gorgy K., Gondran C., et al.
(2016). A label-free photoelectrochemical cocaine aptasensor based on an electropolymerized ruthenium-intercalator complex..
Electrochim. Acta. 219, 82–87.
Kazane, I., Gorgy K., Gondran C., Spinelli N., Zazoua A., Defrancq E., et al.
(2016). Highly Sensitive Bisphenol-A Electrochemical Aptasensor Based on Poly(Pyrrole-Nitrilotriacetic Acid)-Aptamer Film..
Anal. Chem. (Washington, DC, United States). 88, 7268–7273.
Flack, T., Constantin T., Penasse S., Dejeu J., Gennaro B., Jourdan M., et al.
(2016). Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties..
Chem. - A Eur. J.. 22, 1760–1767.
Osypova, A., Thakar D., Dejeu J., Bonnet H., Van der Heyden A., Dubacheva G. V., et al.
(2015). Sensor Based on Aptamer Folding to Detect Low-Molecular Weight Analytes..
Anal. Chem. (Washington, DC, United States). 87, 7566–7574.
Yang, C., Spinelli N., Perrier S., Defrancq E., & Peyrin E..
(2015). Macrocyclic Host-Dye Reporter for Sensitive Sandwich-Type Fluorescent Aptamer Sensor..
Anal. Chem. (Washington, DC, United States). 87, 3139–3143.
Bonnet, R., Lavergne T., Gennaro B., Spinelli N., & Defrancq E.
(2015). Construction of anti-parallel G-quadruplexes through sequential templated click..
Chem. Commun. (Cambridge, United Kingdom). 51, 4850–4853.
Thomas, B., Fiore M., Daskhan G. Chand, Spinelli N., & Renaudet O.
(2015). A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds..
Chem. Commun. (Cambridge, United Kingdom). 51, 5436–5439.
Haddache, F., Le Goff A., Reuillard B., Gorgy K., Gondran C., Spinelli N., et al.
(2014). Label-free photoelectrochemical detection of double-stranded HIV DNA by means of a metallointercalator-functionalized electrogenerated polymer..
Chem. - A Eur. J.. 20, 15555–15560.
Stefan, L., Lavergne T., Spinelli N., Defrancq E., & Monchaud D..
(2014). Surface-immobilized DNAzyme-type biocatalysis..
Nanoscale. 6, 2693–2701.
Xu, H., Gorgy K., Gondran C., Le Goff A., Spinelli N., Lopez C., et al.
(2013). Label-free impedimetric thrombin sensor based on poly(pyrrole-nitrilotriacetic acid)-aptamer film.
Biosensors and Bioelectronics. 41, 90 - 95.
Berthet, N., Thomas B., Bossu I., Dufour E., Gillon E., Garcia J., et al.
(2013). High Affinity Glycodendrimers for the Lectin LecB from Pseudomonas aeruginosa..
Bioconjug. Chem.. 24, 1598–1611.
Spinelli, N., Defrancq E., & Morvan F..
(2013). Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications..
Chem. Soc. Rev.. 42, 4557–4573.
Yao, W., Le Goff A., Spinelli N., Holzinger M., Diao G-W., Shan D., et al.
(2013). Electrogenerated trisbipyridyl Ru(II)-/nitrilotriacetic-polypyrene copolymer for the easy fabrication of label-free photoelectrochemical immunosensor and aptasensor: Application to the determination of thrombin and anti-cholera toxin antibody..
Biosens. Bioelectron.. 42, 556–562.
Stefan, L., Duret D., Spinelli N., Defrancq E., & Monchaud D..
(2013). Closer to nature: an ATP-driven bioinspired catalytic oxidation process..
Chem. Commun. (Cambridge, United Kingdom). 49, 1500–1502.
Moreau, J., Dendane N., Schollhorn B., Spinelli N., Fave C., & Defrancq E.
(2013). Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels..
Bioorg. Med. Chem. Lett.. 23, 955–958.
Bonnet, R., Murat P., Spinelli N., & Defrancq E.
(2012). Click-click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures..
Chem. Commun. (Cambridge, United Kingdom). 48, 5992–5994.
Murat, P., Gennaro B., Garcia J., Spinelli N., Dumy P., & Defrancq E.
(2011). The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water..
Chem. - A Eur. J.. 17, 5791–5795, S5791/1–S5791/21.
Murat, P., Bonnet R., Van der Heyden A., Spinelli N., Labbe P., Monchaud D., et al.
(2010). Template-Assembled Synthetic G-Quadruplex (TASQ): A Useful System for Investigating the Interactions of Ligands with Constrained Quadruplex Topologies..
Chem. - A Eur. J.. 16, 6106–6114, S6106/1–S6106/16.
Meyer, A., Spinelli N., Dumy P., Vasseur J-J., Morvan F., & Defrancq E.
(2010). Oligonucleotide Sequential Bis-Conjugation via Click-Oxime and Click-Huisgen Procedures..
J. Org. Chem.. 75, 3927–3930.
Renaudet, O., Garcia J., Boturyn D., Spinelli N., Defrancq E., Labbe P., et al.
(2010). Molecular engineering of biomolecules for nanobio-sciences..
Int. J. Nanotechnol.. 7, 738–752.
Murat, P., Spinelli N., Dumy P., & Defrancq E.
(2009). Efficient conjugation of oligonucleotides through aromatic oxime formation..
Bioorg. Med. Chem. Lett.. 19, 6534–6537.
Murat, P., Cressend D., Spinelli N., Van der Heyden A., Labbe P., Dumy P., et al.
(2008). A novel conformationally constrained parallel G quadruplex..
ChemBioChem. 9, 2588–2591.
Spinelli, N., Singh Y., Defrancq E., & Dumy P.
(2007). Aldehydic Oligonucleotide: A Key Intermediate for the Preparation of Oligonucleotide Conjugates Through Oxime Bond Formation..
Nucleosides. Nucleotides Nucleic Acids. 26, 883–887.
Spinelli, N., Edupuganti O. Prakash, Defrancq E., & Dumy P.
(2007). New Solid Support for the Synthesis of 3'-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation..
Org. Lett.. 9, 219–222.
Nicolas Spinelli obtained its Ph.D. in bioorganic chemistry in 2001 from University Montpellier II (supervisor Dr. J.-J. Vasseur) on the synthesis of oligonucleotides prodrugs. After his Ph.D., he joined the group of Dr. B. Mandrand (UMR 2714 CNRS/bioMérieux, ENS Lyon) where he worked on the synthesis of oligonucleotides conjugated with pyrrole and ferrocene moieties and their use in electrochemical DNA biosensors. He joined the DCM (Grenoble) in 2005 where he obtained an Assistant Professor position in 2006. His current researches efforts are focused on the synthesis of oligonucleotides conjugates especially for sensors applications. He obtained accreditation to supervise research (HDR) in 2013.
Keywords : Oligonucleotides, Aptamers, Catalysis, Aptasensors
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