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Heterocyclic Chemistry and Novel Antibacterials

Developing synthetic methods in heterocyclic chemistry and applying them to the synthesis of natural and/or biologically relevant products is our main research objective. Among these studies, a fruitful collaboration with a bacteriology team (Prof. Max Maurin, CHUGA) led to the identification of two novel families of antibacterial compounds, namely bis-indoles and dipyrromethanes (4 patents). These molecules display strong in vitro activities against Gram-positive bacteria, especially against multi-drug resistant strains (MRSA, VISA, GRE). This translational research was recently included in a maturation stage at SATT Linksium.


Denis, J-N., C. Jolivalt, M. Maurin, and M. Jeanty, (2013) Bis-indolic Derivatives, A Process For Preparing The Same and Their Uses as a Drug 105 pp.
Denis, J-N., C. Jolivalt, M. Maurin, and O. Burchak, (2013) Bis-indolic Derivatives, Their Uses in Particular as Antibacterials, 80 pp.

Pelloux-Leon, N., Minassian F., Maurin M., & Denis J-N. (2013).  Pyrrolic Derivatives, Processes For Preparing The Same and Their Uses as a Drug 260 pp.
Godet-Bar, T., J.-C.. Lepretre, P. Poizot, F. Massuyeau, E. Faulques, A. Christen, F. Minassian, J-F. Poisson, F. Loiseau, and F. Lafolet, "Light assisted rechargeable batteries: a proof of concept with BODIPY derivatives acting as a combined photosensitizer and electrical storage unit.", J. Mater. Chem. A Mater. Energy Sustain., vol. 5, no. 5: Royal Society of Chemistry, pp. 1902–1905, 2017.

Publié le 9 juillet 2019

Mis à jour le 14 décembre 2023