Site du DCM - Université Grenoble Alpes

OLIVIER RENAUDET

Professeur des universités

Affiliation

Université Grenoble Alpes

Équipe de recherche

DCM-I2BM

Domaines de recherche

glycochimie, chimie bioorganique, immunochimie, multivalence

Disciplines scientifiques

Chimie organique, minérale, industrielle

Habilitation à diriger des recherches

Synthèse et étude de glycoclusters biologiquement actifs
from 05/10/2011 to 06/10/2011

Thèse

Développement de méthodes chimiosélectives pour la conjugaison de peptides
sous la direction de Prof. P. Dumy
from 02/11/1998 to 07/02/2002

Hovorková, M., Červený J., Bumba L., Pelantová H., Cvačka J., Křen V., et al. (2023). Advanced high-affinity glycoconjugate ligands of galectins. Bioorganic Chemistry. 131, 106279.

Goyard, D., Roubinet B., Vena F., Landemarre L., & Renaudet O. (2022). Homo- and Heterovalent Neoglycoproteins as Ligands for Bacterial Lectins. ChemPlusChem. 87, e202100481.

Goyard, D., Martin-Serrano-Ortiz A., Boturyn D., & Renaudet O. (2022). Multivalent glycocyclopeptides: conjugation methods and biological applications. Chem. Soc. Rev.. 51, 8756 – 8783.

Bulteau, F., Thepaut M., Henry M., Hurbin A., Vanwonterghem L., Vivès C., et al. (2022). Targeting Tn-Antigen-Positive Human Tumors with a Recombinant Human Macrophage Galactose C-Type Lectin. Molecular Pharmaceutics. 19, 235-245.

Goyard, D., & Renaudet O. (2022). Cyclopeptides as glycan-presenting multivalent scaffolds. Carbohydrate Chemistry: Chemical and Biological Approaches. 45, 499-518.

Picault, L., Laigre E., Gillon E., Tiertant C., Renaudet O., Imberty A., et al. (2022). Characterization of the interaction of multivalent glycosylated ligands with bacterial lectins by BioLayer interferometry. Glycobiology. 32(10), 886-896.

Gentil, S., Pifferi C., Rousselot-Pailley P., Tron T., Renaudet O., & Le Goff A. (2021). Clicked Bifunctional Dendrimeric and Cyclopeptidic Addressable Redox Scaffolds for the Functionalization of Carbon Nanotubes with Redox Molecules and Enzymes. Langmuir. 37, 1001-1011.

Achilli, S., Berthet N., & Renaudet O. (2021). Antibody recruiting molecules (ARMs): synthetic immunotherapeutics to fight cancer. RSC Chem. Biol.. 2, 713-724 .

Martin, H., Goyard D., Margalit A., Doherty K., Renaudet O., Kavanagh K., et al. (2021). Multivalent Presentations of Glycomimetic Inhibitor of the Adhesion of Fungal Pathogen Candida albicans to Human Buccal Epithelial Cells. Bioconjugate Chemistry. 32(5), 971–982.

Todaro, B., Achilli S., Liet B., Laigre E., Tiertant C., Goyard D., et al. (2021). Structural influence of antibody recruiting glycodendrimers (ARGs) on antitumoral cytotoxicity. Biomater. Sci.. 9, 4076-4085 .

Gentil, S.., Pifferi C.., Rousselot-Pailley P.., Tron T.., Renaudet O., & Le Goff A. (2021). Clicked Bifunctional Dendrimeric and Cyclopeptidic Addressable Redox Scaffolds for the Functionalization of Carbon Nanotubes with Redox Molecules and Enzymes. Langmuir. 37(3),

Pifferi, C., Ruiz-de-Angulo A., Goyard D., Tiertant C., Sacristán N., Barriales D., et al. (2020). Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue. Chem. Sci.. 11, 4488 - 4498 .

Porkolab, V., Pifferi C., Sutkeviciute I., Ordanini S., Taouai M., Thepaut M., et al. (2020). Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface. Org. Biomol. Chem.. 18, 4763 - 4772.

Roussel, E., Tran-Nguyen V-K., Bouhedjar K., Dems M. Abdesselem, Belaidi A., Matougui B., et al. (2019). Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2. European Journal of Medicinal Chemistry. 184, 111772.

Fayolle, D., Berthet N., Doumeche B., Renaudet O., Strazewski P., & Fiore M. (2019). Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside. Beilstein Journal of Organic Chemistry. 15, 937-946.

Roussel, E., Tran-Nguyen V-K., Bouhedjar K., Dems M. Abdesselem, Belaidi A., Matougui B., et al. (2019). Optimization of the chromone scaffold through QSAR and docking studies: identification of potent inhibitors of ABCG2.. Eur. J. Med. Chem.. 184, 111772.

Liet, B., Laigre E., Goyard D., Todaro B., Tiertant C., Boturyn D., et al. (2019). Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells.. Chem. - Eur. J.. 25, 15508–15515.

Gonzalez-Cuesta, M., Goyard D., Nanba E., Higaki K., Fernandez J. M. Garcia, Renaudet O., et al. (2019). Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.. Chem. Commun. (Cambridge, U. K.). 55, 12845–12848.

Fayolle, D., Berthet N., Doumeche B., Renaudet O., Strazewski P., & Fiore M.. (2019). Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside.. Beilstein J. Org. Chem.. 15, 937–946.

Marin-Montesinos, I., Goyard D., Gillon E., Renaudet O., Imberty A., Hediger S., et al. (2019). Selective high-resolution DNP-enhanced NMR of biomolecular binding sites. Chem. Sci.. 10, 3366-3374.

Goyard, D., Thomas B., Gillon E., Imberty A., & Renaudet O. (2019). Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa. Frontiers in Chemistry. 7, 666.

Liet, B., Laigre E., Goyard D., Todaro B., Tiertant C., Boturyn D., et al. (2019). Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells. Chemistry – A European Journal. 25, 15508-15515.

Laigre, E., Tiertant C., Goyard D., & Renaudet O. (2018). Identification of Nanomolar Lectin Ligands by a Glycodendrimer Microarray.. ACS Omega. 3, 14013–14020.

Laigre, E., Goyard D., Tiertant C., Dejeu J., & Renaudet O. (2018). The study of multivalent carbohydrate-protein interactions by bio-layer interferometry.. Org. Biomol. Chem.. 16, 8899–8903.

Ribeiro, J. P., Villringer S., Goyard D., Guerente L., Hoferlin M., Renaudet O., et al. (2018). Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells.. Chem. Sci.. 9, 7634–7641.

Goyard, D., Baldoneschi V., Varrot A., Fiore M., Imberty A., Richichi B., et al. (2018). Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens.. Bioconjug. Chem.. 29, 83–88.

Pifferi, C., Thomas B., Goyard D., Berthet N., & Renaudet O. (2017). Heterovalent Glycodendrimers as Epitope Carriers for Antitumor Synthetic Vaccines.. Chem. - A Eur. J.. 23, 16283–16296.

Pifferi, C., Daskhan G. Chand, Fiore M., Shiao T. Chieh, Roy R., & Renaudet O. (2017). Aminooxylated Carbohydrates: Synthesis and Applications.. Chem. Rev. (Washington, DC, United States). 117, 9839–9873.

Pifferi, C., Goyard D., Gillon E., Imberty A., & Renaudet O. (2017). Synthesis of Mannosylated Glycodendrimers and Evaluation against BC2L-A Lectin from Burkholderia Cenocepacia.. Chempluschem. 82, 390–398.

Richard, E., Pifferi C., Fiore M., Samain E., Le Gouellec A., Fort S., et al. (2017). Chemobacterial Synthesis of a Sialyl-Tn Cyclopeptide Vaccine Candidate.. ChemBioChem. 18, 1730–1734.

Fallarini, S., Brittoli A., Fiore M., Lombardi G., Renaudet O., Richichi B., et al. (2017). Immunological characterization of a rigid $\alpha$-Tn mimetic on murine iNKT and human NK cells.. Glycoconj. J.. 34, 553–562.

Hoang, A., Laigre E., Goyard D., Defrancq E., Vinet F., Dumy P., et al. (2017). An oxime-based glycocluster microarray.. Org. Biomol. Chem.. 15, 5135–5139.

Pifferi, C., Berthet N., & Renaudet O. (2017). Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines.. Biomater. Sci.. 5, 953–965.

Daskhan, G. Chand, Pifferi C., & Renaudet O. (2016). Synthesis of a New Series of Sialylated Homo- and Heterovalent Glycoclusters by using Orthogonal Ligations.. ChemistryOpen. 5, 477–484.

Ribeiro, J. P., Pau W., Pifferi C., Renaudet O., Varrot A., Mahal L. K., et al. (2016). Characterization of a high-affinity sialic acid-specific CBM40 from Clostridium perfringens and engineering of a divalent form.. Biochem. J.. 473, 2109–2118.

Monestier, M., Charbonnier P., Gateau C., Cuillel M., Robert F., Lebrun C., et al. (2016). ASGPR-Mediated Uptake of Multivalent Glycoconjugates for Drug Delivery in Hepatocytes.. ChemBioChem. 17, 590–594.

Richichi, B., Comito G., Renaudet O., Fiore M., Marra A., Stecca B., et al. (2016). Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression.. ACS Med. Chem. Lett.. 7, 28–33.

Daskhan, G. Chand, Berthet N., Thomas B., Fiore M., & Renaudet O. (2015). Multivalent glycocyclopeptides: toward nano-sized glycostructures.. Carbohydr. Res.. 405, 13–22.

Thomas, B., Pifferi C., Daskhan G. Chand, Fiore M., Berthet N., & Renaudet O. (2015). Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations.. Org. Biomol. Chem.. 13, 11529–11538.

Thomas, B., Fiore M., Daskhan G. Chand, Spinelli N., & Renaudet O. (2015). A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds.. Chem. Commun. (Cambridge, United Kingdom). 51, 5436–5439.

Krenek, K., Gazak R., Daskhan G. Chand, Garcia J., Fiore M., Dumy P., et al. (2014). Access to bifunctionalized biomolecular platforms using oxime ligation.. Carbohydr. Res.. 393, 9–14.

Rozbesky, D., Krejzova J., Krenek K., Prchal J., Hrabal R., Kozisek M., et al. (2014). Re-evaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.. Int. J. Mol. Sci.. 15, 1271–1283, 13 pp..

Fiore, M., Daskhan G. Chand, Thomas B., & Renaudet O. (2014). Orthogonal dual thiol-chloroacetyl and thiol-ene coupling for the sequential one-pot assembly of heteroglycoclusters.. Beilstein J. Org. Chem.. 10, 1557–1563, 7 pp..

Fiore, M., Berthet N., Renaudet O., & Barbier V.. (2014). New glycopolymers as multivalent systems for lectin recognition.. Medchemcomm. 5, 1202–1207.

Ghirardello, M., Oeberg K., Staderini S., Renaudet O., Berthet N., Dumy P., et al. (2014). Thiol-ene and thiol-yne-based synthesis of glycodendrimers as nanomolar inhibitors of wheat germ agglutinin.. J. Polym. Sci. Part A Polym. Chem.. 52, 2422–2433.

Renaudet, O., Krenek K., Bossu I., Dumy P., Kadek A., Adamek D., et al. (2014). Synthesis of Multivalent Glycoconjugates Containing the Immunoactive LELTE Peptide: Effect of Glycosylation on Cellular Activation and Natural Killing by Human Peripheral Blood Mononuclear Cells [Retraction of document cited in CA152:592290].. J. Am. Chem. Soc.. 136, 1156.

Ulrich, S., Boturyn D., Marra A., Renaudet O., & Dumy P. (2014). Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs.. Chem. - A Eur. J.. 20, 34–41.

Berthet, N., Thomas B., Bossu I., Dufour E., Gillon E., Garcia J., et al. (2013). High Affinity Glycodendrimers for the Lectin LecB from Pseudomonas aeruginosa.. Bioconjug. Chem.. 24, 1598–1611.

Bernardi, A., Jimenez-Barbero J., Casnati A., De Castro C., Darbre T., Fieschi F., et al. (2013). Multivalent glycoconjugates as anti-pathogenic agents.. Chem. Soc. Rev.. 42, 4709–4727.

Thomas, B., Berthet N., Garcia J., Dumy P., & Renaudet O. (2013). Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers.. Chem. Commun. (Cambridge, United Kingdom). 49, 10796–10798.

Fiore, M., Berthet N., Marra A., Gillon E., Dumy P., Dondoni A., et al. (2013). Tetravalent glycocyclopeptide with nanomolar affinity to wheat germ agglutinin.. Org. Biomol. Chem.. 11, 7113–7122.

M Galan, C., Dumy P., & Renaudet O. (2013). Multivalent glyco(cyclo)peptides.. Chem. Soc. Rev.. 42, 4599–4612.

Renaudet, O., & Roy R.. (2013). Multivalent scaffolds in glycoscience: an overview.. Chem. Soc. Rev.. 42, 4515–4517.

Fiore, M., Thomas B., Dulery V., Dumy P., & Renaudet O. (2013). Synthesis of multi-antigenic platforms as vaccine candidates against cancers.. New J. Chem.. 37, 286–289.

Marra, A., Staderini S., Berthet N., Dumy P., Renaudet O., & Dondoni A.. (2013). Thiyl Glycosylation of Propargylated Octasilsesquioxane: Synthesis and Lectin-Binding Properties of Densely Glycosylated Clusters on a Cubic Platform.. European J. Org. Chem.. 2013, 1144–1149.

Ulrich, S., Dumy P., Boturyn D., & Renaudet O. (2013). Engineering of biomolecules for sensing and imaging applications.. J. Drug Deliv. Sci. Technol.. 23, 5–15.

Thomas, B., Fiore M., Bossu I., Dumy P., & Renaudet O. (2012). Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations.. Beilstein J. Org. Chem.. 8, 421–427, No. 47.

Conte, M. Lo, Staderini S., Chambery A., Berthet N., Dumy P., Renaudet O., et al. (2012). Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol-ene coupling. The observation of a striking glycoside cluster effect.. Org. Biomol. Chem.. 10, 3269–3277.

Bossu, I., Berthet N., Dumy P., & Renaudet O. (2011). Synthesis of Glycocyclopeptides by Click Chemistry and Inhibition Assays with Lectins.. J. Carbohydr. Chem.. 30, 458–468.

Andre, S., Renaudet O., Bossu I., Dumy P., & Gabius H-J.. (2011). Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells.. J. Pept. Sci.. 17, 427–437.

Bossu, I., Sulc M., Krenek K., Dufour E., Garcia J., Berthet N., et al. (2011). Dendri-RAFTs: a second generation of cyclopeptide-based glycoclusters.. Org. Biomol. Chem.. 9, 1948–1959.

Galibert, M., Renaudet O., Dumy P., & Boturyn D. (2011). Access to Biomolecular Assemblies through One-Pot Triple Orthogonal Chemoselective Ligations.. Angew. Chemie, Int. Ed.. 50, 1901–1904, S1901/1–S1901/32.

Renaudet, O., Philouze C., Bailly C., Durif A., & Dumy P. (2011). X-Ray Structure of the Key Synthetic Intermediate of a Cancer-Related Sialyl-Tn Antigen Analogue.. J. Chem. Crystallogr.. 41, 204–208.

Delangle, P., Pujol A., Dumy P., Renaudet O., & Ferrand M.. (2011). Novel cyclodecapeptide compounds for use as drugs for diagnosis, prevention, and/or treatment of neurodegenerative diseases..

Pujol, A. M., Cuillel M., Renaudet O., Lebrun C., Charbonnier P., Cassio D., et al. (2011). Hepatocyte Targeting and Intracellular Copper Chelation by a Thiol-Containing Glycocyclopeptide.. J. Am. Chem. Soc.. 133, 286–296.

Renaudet, O., Krenek K., Bossu I., Dumy P., Kadek A., Adamek D., et al. (2010). Synthesis of Multivalent Glycoconjugates Containing the Immunoactive LELTE Peptide: Effect of Glycosylation on Cellular Activation and Natural Killing by Human Peripheral Blood Mononuclear Cells.. J. Am. Chem. Soc.. 132, 6800–6808.

Galibert, M., Sancey L., Renaudet O., Coll J-L., Dumy P., & Boturyn D. (2010). Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.. Org. Biomol. Chem.. 8, 5133–5138.

Renaudet, O., Dasgupta G., Bettahi I., Shi A., Nesburn A. B., Dumy P., et al. (2010). Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity.. PLoS One. 5, No pp. given.

Renaudet, O., Garcia J., Boturyn D., Spinelli N., Defrancq E., Labbe P., et al. (2010). Molecular engineering of biomolecules for nanobio-sciences.. Int. J. Nanotechnol.. 7, 738–752.

Renaudet, O., Boturyn D., & Dumy P. (2009). Biomolecular assembly by iterative oxime ligations.. Bioorg. Med. Chem. Lett.. 19, 3880–3883.

Dolphin, G. T., Renaudet O., Ouberai M., Dumy P., Garcia J., & Reymond J-L.. (2009). Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro.. ChemBioChem. 10, 1325–1329.

Bettahi, I., Dasgupta G., Renaudet O., Chentoufi A. Alami, Zhang X., Carpenter D., et al. (2009). Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes.. Cancer Immunol. Immunother.. 58, 187–200.

Renaudet, O., & Dumy P. (2008). Oxime-based synthesis of new chromogenic and fluorogenic oligosaccharides.. European J. Org. Chem.. 5383–5386.

Dendane, N., Hoang A., Renaudet O., Vinet F., Dumy P., & Defrancq E. (2008). Surface patterning of (bio)molecules onto the inner wall of fused-silica capillary tubes.. Lab Chip. 8, 2161–2163.

Renaudet, O. (2008). Recent advances on cyclopeptide-based glycoclusters.. Mini. Rev. Org. Chem.. 5, 274–286.

Dulery, V., Uhlich N. A., Maillard N., Fluxa V. S., Garcia J., Dumy P., et al. (2008). A cyclodecapeptide ligand to vitamin B12.. Org. Biomol. Chem.. 6, 4134–4141.

Renaudet, O., & Dumy P. (2008). A fully solid-phase synthesis of biotinylated glycoclusters.. Open Glycosci.. 1, 1–7.

Dulery, V., Renaudet O., Wilczewski M., Van der Heyden A., Labbe P., & Dumy P. (2008). Randomized Combinatorial Library of Hetero-glyco-clusters (hGC).. J. Comb. Chem.. 10, 368–371.

Wilczewski, M., Van der Heyden A., Renaudet O., Dumy P., Guerente L., & Labbe P. (2008). Promotion of sugar-lectin recognition through the multiple sugar presentation offered by regioselectively addressable functionalized templates (RAFT): a QCM-D and SPR study.. Org. Biomol. Chem.. 6, 1114–1122.

Boturyn, D., Defrancq E., Dolphin G. T., Garcia J., Labbe P., Renaudet O., et al. (2008). RAFT Nano-constructs: surfing to biological applications.. J. Pept. Sci.. 14, 224–240.

Laudet, B., Barette C., Dulery V., Renaudet O., Dumy P., Metz A., et al. (2007). Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction.. Biochem. J.. 408, 363–373.

Kolomiets, E., Johansson E. M. V., Renaudet O., Darbre T., & Reymond J-L.. (2007). Neoglycopeptide dendrimer libraries as a source of lectin binding ligands.. Org. Lett.. 9, 1465–1468.

EDUCATION
2002: Ph.D., University of Grenoble, France, Bioorganic chemistry
2011: Habilitation à Diriger les Recherches, Chemistry and Life Sciences, University of Grenoble, France

PROFESSIONAL EXPERIENCE
2002: Postdoc, Department of Chemistry and Biochemistry (Supervisor: Prof. J. L. Reymond, Univ. Bern, Switzerland
2003: Postdoc, Institute of Molecular Chemistry of Grenoble, (Supervisor: Prof. P. Dumy), Univ. Grenoble, France
2008-2015: In charge of the 3rd year of the undergraduate degree in Chemistry/Biology at the University of Grenoble
2011-2016: Substitute member of the management committee of the European framework COST CM1102 “Multivalent Glycosystems for Nanoscience”
2012-2016: Member of the regional Plenary Council of the Academic Research Community-Health
2013-to date: Member of the Habilitation commission of the Doctoral School, Univ. Grenoble
2014-to date: Member of the Scientific board of the Labex ARCANE, Grenoble
2016-to date: Elected member of the National Committee for Scientific Research, Section 16
2016-to date: Member of the Executive Committee for the project IDEX GlycoAlps and head of the work package 'Sweet Biomolecules'

POSITIONS AND DISTINCTIONS
2004: Assistant professor, University of Grenoble, France, Bioorganic chemistry
2011: Appointed Junior Member at the Institut Universitaire de France
2012: Full professor, University of Grenoble, France, Bioorganic chemistry
2014: Laureate of the ERC Consolidator Grant ‘LEGO’

KEYWORDS
Glycochemistry, peptide chemistry, chemical ligations, synthetic vaccines, carbohydrate-protein interactions, multivalency

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ORCID ID: orcid.org/0000-0003-4963-3848
Researcher ID: B-6120-2014
Scopus Author ID: 6602195394