FLORIAN BERTHIOL

Chimie organique

Vacations en CHI101 atomistique et cristallochimie (TDs), CHI306 (TDs et TPs).

2014-présent: Chargé de recherche de classe normale au CNRS:

Synthèse et Réactivité en Chimie Organique (SERCO), Prof. Jean-François Poisson, Département de Chimie Moléculaire (DCM), Université Grenoble Alpes.

2009-2014: Chargé de recherché de deuxième classe au CNRS:

Synthèse et Réactivité en Chimie Organique (SERCO), Dr. Jacques Einhorn et Prof. Jean-François Poisson, Département de Chimie Moléculaire (DCM),

Université Joseph Fourier Grenoble 1.

2013: Habilitation à Diriger des Recherches spécialité Chimie : Ecole doctorale Chimie et Science du Vivant, Université Joseph Fourier, Grenoble 1.

2008-2009:     Chercheur (postdoc), 1 an:

Laboratoire de Synthèse et Méthodologie Organiques, Prof. Olivier Baudoin, Université Claude Bernard Lyon I.

2007-2008:     Chercheur (postdoc), 1 an:

Laboratory of Synthetic Organic Chemistry, Prof. Johannes G. de Vries et Prof. Ben L. Feringa, The University of Groningen (Pays-Bas).

2005-2007:     Chercheur (postdoc), 2 ans:

Laboratory of Synthetic Organic Chemistry, Prof. Shū Kobayashi, The University of Tokyo (Japon). Financement: JSPS.

2002-2005:     Doctorat en Chimie Organique (mention très honorable) :

Laboratoire de Synthèse Organique, Prof. Maurice Santelli et Dr Henri Doucet, Université d’Aix-Marseille III.

(44) Copper and Nickel Complexes of Oxamate-Phenol Containing Ligands: A Structural Dichotomy in Oxidized Species.

G. Wang, Y. Moreau, F. Berthiol, C. Philouze, O. Jarjayes, F. Thomas, Eur. J. Inorg. Chem. 2023, in press.

(43) Novel Synthesis of IMC-48 and Affinity Evaluation with Different i-Motif DNA Sequences.

F. Berthiol, J. Boissieras, H. Bonnet, M. Pierrot, C. Philouze, J. –F Poisson, A. Granzhan, J. Dejeu, E. Defrancq, Molecules 2023, 28, 682.

(42) 1,2-Additions on Chiral N-sulfinylketimines: an Easy Access to Chiral α-Tertiary Amines.

C. Achuenu, S. Carret, J. –F Poisson, F. Berthiol, Synthesis 2022, 2309.

(41) Copper Complexes of the Tetradentate N,N’-Bis(2-amino-3,5-di-tert-butylphenyl)-2,2’-diaminobiphenyl Ligand.

N. Leconte, F. Berthiol, C. Philouze, F. Thomas, Eur. J. Inorg. Chem. 2021, 1481.

(40) Distorted copper(II) radicals with sterically hindered salens: electronic structure and aerobic oxidation of alcohols.

R. Kunert, C. Philouze, F. Berthiol, O. Jarjayes, T. Storr, F. Thomas, Dalton Trans. 2020, 49, 12990.

(39) Application of chiral sulfinamides into formation and reduction of sulfinylketimines to obtain valuable α-Chiral Primary Amines.

C. Achuenu, S. Carret, J. –F Poisson, F. Berthiol, Eur. J. Org. Chem. 2020, 5901.

(38) Electronic Structure and Reactivity of One-Electron-Oxidized Copper(II) Bis(Phenolate)Dipyrrin Complexes.

L. Lecarme, A. Kochem, L. Chiang, J. Moutet, F. Berthiol, C. Philouze, N. Leconte, T. Storr, F. Thomas, Inorg. Chem. 2018, 57, 9708.

(37) An Unprecedented 7-Membered Ring Enamide Cyclization Through Hypervalent Iodine Phenolic Oxidation.

F. Berthiol, C. Philouze, P. Y. Chavant, J. -F. Poisson, Tetrahedron Lett. 2018, 59, 2293.

(36) A Structurally Characterized Cu^III Complex Supported by a Bis(anilido) Ligand and Its Oxidative Catalytic Activity.

A. Kochem, J. K. Molloy, G. Gellon, N. Leconte, C. Philouze, F. Berthiol, O. Jarjayes, F. Thomas, Chem. Eur. J. 2017, 23, 13929.

(35) Application of Microwave Heating of Dry Organic Reaction: New Condensation Products From Triacetic Acid Lactone (TAL).

N. Benferrah, M. Hammadi, F. Berthiol, Rev. Roum. Chim. 2016, 61, 863.

(34) Copper (II) complex of a Schiff base of dehydroacetic acid: Characterization and aerobic oxidation of benzyl alcohol.

N. Benferrah, M. Hammadi, C. Philouze, F. Berthiol, F; Thomas, Inorg. Chem. Commun. 2016, 72, 17.

(33) 3,3’-Diiodobinaphthol and 3,3’-Diiodobiphenol Derivatives as Hypervalent Iodine Organocatalysts in the α-Oxytosylation of Ketones.

S. Brenet, C. Minozzi, B. Clarens, L. Amiri, F. Berthiol, Synthesis 2015, 3858.

(32) 3,3’-Diiodo-BINOL fused maleimides as chiral hypervalent iodine (III) organocatalysts.

S. Brenet, F. Berthiol, J. Einhorn, Eur. J. Org. Chem. 2013, 8094.

(31) BINOL-Fused Maleimides - A New Class of C₂-Symmetric Chiral Imides.

S. Brenet, B. Baptiste, C. Philouze, F. Berthiol, J. Einhorn, Eur. J. Org. Chem. 2013, 1041.

(30) Efficient Synthesis of Substituted Polyarylphthalimides via Cycloaddition of Cyclopentadienones with 2-Bromomaleimide.

R. Vanel, F. Berthiol, B. Bessières, C. Einhorn, J. Einhorn, Synlett 2011, 1293.

(29) Combining Designer Cells and Click Chemistry for a One-Pot Four-Step Preparation of Enantiopure β-Hydroxytriazoles.

W. Szymanski, C. P. Postema, C. Tarabiono, F. Berthiol, L. Campbell-Verduyn, S. de Wildeman, J. G. de Vries, Ben L. Feringa, D. B. Janssen, Adv. Synth. Catal. 2010, 352, 2111.

(28) Unexpected Reduction of N-hydroxyphthalimides to Phthalimides – Orthogonal Reduction of Functionalized N-hydroxyphthalimides.

J. Jacq, F. Berthiol, C. Einhorn, J. Einhorn, Synlett 2010, 2263.

(27) Ruthenacycles and Iridacycles as Catalysts for Asymmetric Transfer Hydrogenation and Racemisation.

T. Jerphagnon, R. M. Haak, F. Berthiol, A. J. A. Gayet, V. Ritleng, A. Holuigue, N. Pannetier, M. Pfeffer, A. Voelklin, L. Lefort, G. Verzijl, C. Tarabiono, D. B. Janssen, A. J. Minnaard, B. L. Feringa, J. G. de Vries, Top. Catal. 2010, 53, 1002.

(26) Fast Racemisation of Chiral Amines and Alcohols by Using Cationic Half-Sandwich Ruthena- and Iridacycle Catalysts.

T. Jerphagnon, A. J. A. Gayet, F. Berthiol, V. Ritleng, N. Mršić, A. Meetsma, M. Pfeffer, A. J. Minnaard, B. L. Feringa, J. G. de Vries, Chem. Eur. J. 2009, 15, 12780.

(25) Catalytic Mannich-type Reactions of Sulfonylimidates.

R. Matsubara, F. Berthiol, H. V. Nguyen, S. Kobayashi, Bull. Chem. Soc. Jpn. 2009, 1083.

(24) Asymmetric Hydrogenation of α,β-Unsaturated Ester-Phosphonates.

Y. Huang, F. Berthiol, B. Stegink, M. M. Pollard, A. J. Minnaard, Adv. Synth. Catal. 2009, 351, 1423.

(23) Catalytic direct-type substitution reaction of α-alkyl enolates: a Pd/Brønsted base catalysed approach to the decarboxylative allylation of sulfonylimidates.

S. B. J. Kan, R. Matsubara, F. Berthiol, S. Kobayashi, Chem. Commun. 2008, 6354.

(22) Dynamic Kinetic Resolution of Racemic β-Haloalcohols: Direct Access to Enantioenriched Epoxides.

R. M. Haak, F. Berthiol, T. Jerphagnon, A. J. A. Gayet, C. Tarabiono, C. P. Postema, V. Ritleng, M. Pfeffer, D. B. Janssen, A. J. Minnaard, B. L. Feringa, J. G. de Vries, J. Am. Chem. Soc. 2008, 130, 13508.

(21) Sulfonyl Imidates as Nucleophiles in Catalytic Addition Reaction.

R. Matsubara, F. Berthiol, S. Kobayashi, J. Am. Chem. Soc. 2008, 130, 1804.

(20) Palladium/tetraphosphine catalyzed Heck reaction of vinyl bromides with alkenes: a powerful access to conjugated dienes.

M. Lemhadri, A. Battace, F. Berthiol, T. Zair, H. Doucet, M. Santelli, Synthesis 2008, 1142.

(19) Catalytic Asymmetric Michael Reactions with Enamides as Nucleophiles.

F. Berthiol, R. Matsubara, N. Kawai, S. Kobayashi, Angew. Chem. Int. Ed. 2007, 46, 7803.

(18) Palladium-tetraphosphine catalysed Heck reaction with simple alkenes: influence of reaction conditions on the migration of the double bond.

Y. Fall, F. Berthiol, H. Doucet, M. Santelli, Synthesis 2007, 1683.

(17) Heck reactions of aryl halides with alk-1-en-3-ol derivatives catalysed by a tetraphosphine –palladium complex.

F. Berthiol, H. Doucet, M. Santelli, Appl. Organometal. Chem. 2006, 20, 855.

(16) Suzuki coupling of 2-chloroacrylonitrile, methyl 2-chloroacrylate, or 2-chloroprop1-en-3-ol with aryl boronic acids catalyzed by a palladium-tetraphosphine complex.

F. Berthiol, H. Doucet, M. Santelli, Synth. Commun. 2006, 36, 3019.

(15) Heck reaction of protected alk-1-en-3-ol, -4-ols, -5-ol or -6-ol with aryl bromides catalyzed by a palladium complex derived from a tetraphosphine.

F. Berthiol, H. Doucet, M. Santelli, Synthesis 2006, 1518.

(14) Synthesis of b-aryl ketones by tetraphosphine/palladium catalyzed Heck reactions of 2- or 3-substituted allylic alcohols with aryl bromides.

F. Berthiol, H. Doucet, M. Santelli, Tetrahedron 2006, 62, 4372.

(13) Heck Reaction of aryl bromides with pent-4-en-2-ol, 2-phenyl-4-penten-2-ol, or 6-hepten-3-ol catalyzed by a palladium-tetraphosphine complex.

F. Berthiol, H. Doucet, M. Santelli, Synthesis 2005, 3589.

(12) Direct synthesis of cinnamaldehyde derivatives by reaction of aryl bromides with 3,3’-diacetoxypropene catalyzed by a palladium-tetraphosphine complex.

F. Berthiol, H. Doucet, M. Santelli, Catalysis letters 2005, 102(3-4), 281.

(11) Heck reaction of protected alcohols with aryl bromides catalyzed by a tetraphosphanepalladium complex.

F. Berthiol, H. Doucet, M. Santelli, Eur. J. Org. Chem. 2005, 1367.

(10) Reaction of aryl di-, tri-, or tetrabromides with arylboronic acids or alkenes in the presence of a palladium-tetraphosphine catalyst.

F. Berthiol, I. Kondolff, H. Doucet, M. Santelli, J. Organomet. Chem. 2004, 689, 2786.

(9) Heck reactions of aryl bromides with alk-1-en-3-ol derivatives catalyzed by a tetraphosphine/palladium complex.

F. Berthiol, H. Doucet, M. Santelli, Tetrahedron Lett. 2004, 45, 5633.

(8) Palladium-tetraphosphine complex: An efficient catalyst for the alkynylation of ortho-substituted aryl bromides.

M. Feuerstein, F. Berthiol, H. Doucet, M. Santelli, Synthesis 2004, 1281.

(7) Suzuki cross-coupling reactions between alkenylboronic acids and aryl bromides catalyzed by a tetraphosphane-palladium catalyst.

E. Peyroux, F. Berthiol, H. Doucet, M. Santelli, Eur. J. Org. Chem. 2004, 1075.

(6) Palladium-tetraphosphine complex: an efficient catalyst for the coupling of aryl halides with alkynes.

M. Feuerstein, F. Berthiol, H. Doucet, M. Santelli, Org. Biomol. Chem. 2003, 1, 2235.

(5) Synthesis of polysubstituted alkenes by Heck vinylation or Suzuki cross-coupling reactions in the presence of a tetraphosphane-palladium catalyst.

F. Berthiol, H. Doucet, M. Santelli, Eur. J. Org. Chem. 2003, 1091.

(4) Heck reaction of vinyl bromides with alkenes in the presence of a tetraphosphine/palladium catalyst.

F. Berthiol, H. Doucet, M. Santelli, Synlett 2003, 841.

(3) Heck reaction of aryl halides with linear or cyclic alkenes catalysed by a tetraphosphine/palladium catalyst.

F. Berthiol, H. Doucet, M. Santelli, Tetrahedron Lett. 2003, 44, 1221.

(2) Palladium catalyzed cross-coupling of aryl bromides with functionalized arylboronic acids in the presence of a tetraphosphine ligand.

M. Feuerstein, F. Berthiol, H. Doucet, M. Santelli, Synlett 2002, 1807.

(1) Heck reaction with heteroaryl halides in the presence of a palladium-tetraphosphine catalyst.

F. Berthiol, M. Feuerstein, H. Doucet, M. Santelli, Tetrahedron Lett. 2002, 43, 5625.