Site du DCM - Université Grenoble Alpes

ERIC DEFRANCQ

Professeur des universités

Affiliation

Université Grenoble Alpes

Équipe de recherche

DCM-I2BM

Domaines de recherche

Synthèse d'oligonucléotides et leurs versions modifiées, Aptamères, étude de ligands d'ADN G-quadruplex

Disciplines scientifiques

Chimie organique, minérale, industrielle

Habilitation à diriger des recherches

sous la direction de Pr J. LHOMME

Thèse

Réactivité de métabolites d’amines aromatiques cancérogènes Etude sur des systèmes modèles
sous la direction de Pr J. LHOMME
from 01/09/1987 to 30/05/1989

Responsabilités

Coordinateur de l'axe thématique synthèse et applications de conjugués d'oligonucléotides

Bonnet, H., Coche-Guérente L.., Defrancq E., Spinelli N.., Van der Heyden A., & Dejeu J. (2021). Negative SPR Signals during Low Molecular Weight Analyte Recognition. Analytical Chemistry. 93(8), 4134–4140.

Bossaert, M., Pipier A., Riou J-F., Noirot C., Nguyễn L-T., Serre R-F., et al. (2021). Transcription-associated topoisomerase 2α activity is a major effector of cytotoxicity induced by G-quadruplex ligands. (Aguilera, A., Ed.).eLife. 10, e65184.

Pipier, A., Devaux A., Lavergne T., Adrait A., Couté Y., Britton S., et al. (2021). Constrained G4 structures unveil topology specificity of known and new G4 binding proteins. Scientific Reports. 11, 13469.

Dejeu, J., Van der Heyden A.., Spinelli N.., Defrancq E., & Coche-Guérente L.. (2021). Recent progress in the design of G-quadruplex based electrochemical aptasensors. Current Opinion in Electrochemistry. 100812.

Lartia, R., Vallée C., & Defrancq E. (2020). Post-synthetic transamination at position N4 of cytosine in oligonucleotides assembled with routinely used phosphoramidites. Org. Biomol. Chem.. 18, 9632-9638.

Gillard, M., Weynand J., Bonnet H., Loiseau F., Decottignies A., Dejeu J., et al. (2020). Flexible RuII Schiff Base Complexes: G-Quadruplex DNA Binding and Photo-Induced Cancer Cell Death. Chemistry – A European Journal. 26, 13849-13860.

Weynand, J., Moreno-Betancourt A., Loiseau F., Berthet N., Defrancq E., & Elias B. (2020). Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent. Inorganic Chemistry. 59, 2426-2433.

Perenon, M., Bonnet H., Lavergne T., Dejeu J., & Defrancq E. (2020). Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA. Phys. Chem. Chem. Phys.. 22, 4158-4164.

Vignon, A., Flaget A., Michelas M., Djeghdir M., Defrancq E., Guerente L., et al. (2020). Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry. ACS Sensors. 5(8), 2326 – 2330.

Devaux, A., Bonnat L., Lavergne T., & Defrancq E. (2020). Access to a stabilized i-motif DNA structure through four successive ligation reactions on a cyclopeptide scaffold. Org. Biomol. Chem.. 18, 6394-6406.

Lartia, R., Vallée C., & Defrancq E. (2020). Post-synthetic transamination at position N4 of cytosine in oligonucleotides assembled with routinely used phosphoramidites. Org. Biomol. Chem.. -.

Weynand, J., Bonnet H., Loiseau F., Ravanat J-L., Dejeu J., Defrancq E., et al. (2019). Targeting G-Rich DNA Structures with Photoreactive Bis-Cyclometallated Iridium(III) Complexes. Chemistry – A European Journal. 25, 12730-12739.

Gillard, M., Laramee-Milette B., Deraedt Q., Hanan G. S., Loiseau F., Dejeu J., et al. (2019). Photodetection of DNA mismatches by dissymmetric Ru(ii) acridine based complexes. Inorg. Chem. Front.. 2260-2270.

MacDonald, H., Bonnet H., Van der Heyden A., Defrancq E., Spinelli N., Guerente L., et al. (2019). Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study. J. Phys. Chem. C. 123, 13561–13568.

Bonnat, L., Dautriche M., Saidi T., Revol-Cavalier J., Dejeu J., Defrancq E., et al. (2019). Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands. Org. Biomol. Chem.. 17, 8726-8736.

Weynand, J., Diman A., Abraham M., Marcelis L., Jamet H., Decottignies A., et al. (2018). Towards the Development of Photo-Reactive Ruthenium(II) Complexes Targeting Telomeric G-Quadruplex DNA.. Chem. - A Eur. J.. 24, 19216–19227.

Kajouj, S., Marcelis L., Mattiuzzi A., Grassin A., Dufour D., Van Antwerpen P., et al. (2018). Synthesis and photophysical studies of a multivalent photoreactive RuII-calix[4]arene complex bearing RGD-containing cyclopentapeptides.. Beilstein J. Org. Chem.. 14, 1758–1768.

Prado, E., Bonnat L., Bonnet H., Lavergne T., Van der Heyden A., Pratviel G., et al. (2018). Influence of the SPR Experimental Conditions on the G-Quadruplex DNA Recognition by Porphyrin Derivatives.. Langmuir. 34, 13057–13064.

Dejeu, J., Bonnet H., Spinelli N., Defrancq E., Guerente L., Van der Heyden A., et al. (2018). Impact of Conformational Transitions on SPR Signals-Theoretical Treatment and Application in Small Analytes/Aptamer Recognition.. J. Phys. Chem. C. 122, 21521–21530.

Probst, N., Lartia R., Thery O., Alami M., Defrancq E., & Messaoudi S.. (2018). Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thio-glycoconjugation.. Chem. - A Eur. J.. 24, 1795–1800.

Saint-Germes, L., Bar L., Dejeu J., Spinelli N., Defrancq E., & Pratviel G.. (2017). The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH.. Dalt. Trans.. 46, 12088–12094.

Piraux, G., Bar L., Abraham M., Lavergne T., Jamet H., Dejeu J., et al. (2017). New Ruthenium-Based Probes for Selective G-Quadruplex Targeting.. Chem. - A Eur. J.. 23, 11872–11880.

Bonnat, L., Bar L., Gennaro B., Bonnet H., Jarjayes O., Thomas F., et al. (2017). Template-mediated stabilization of a DNA G-quadruplex formed in the HIV-1 promoter and comparative binding studies.. Chem. - A Eur. J.. 23, 5602–5613.

Defrancq, E., & Messaoudi S.. (2017). Palladium-Mediated Labeling of Nucleic Acids.. ChemBioChem. 18, 426–431.

Hoang, A., Laigre E., Goyard D., Defrancq E., Vinet F., Dumy P., et al. (2017). An oxime-based glycocluster microarray.. Org. Biomol. Chem.. 15, 5135–5139.

Marcelis, L., Kajouj S., Ghesquiere J., Fettweis G., Coupienne I., Lartia R., et al. (2016). Highly DNA-Photoreactive Ruthenium 1,4,5,8-Tetraazaphenanthrene Complex Conjugated to the TAT Peptide: Efficient Vectorization inside HeLa Cells without Phototoxicity - The Importance of Cellular Distribution.. Eur. J. Inorg. Chem.. 2016, 2902–2911.

Dejeu, J., Lavergne T., Nora J. Della, Defrancq E., & Pratviel G.. (2016). Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal.. Inorganica Chim. Acta. 452, 98–103.

Bonnat, L., Dejeu J., Bonnet H., Gennaro B., Jarjayes O., Thomas F., et al. (2016). Templated Formation of Discrete RNA and DNA:RNA Hybrid G-Quadruplexes and Their Interactions with Targeting Ligands.. Chem. - A Eur. J.. 22, 3139–3147.

Flack, T., Constantin T., Penasse S., Dejeu J., Gennaro B., Jourdan M., et al. (2016). Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.. Chem. - A Eur. J.. 22, 1760–1767.

Haddache, F., Le Goff A., Spinelli N., Gairola P., Gorgy K., Gondran C., et al. (2016). A label-free photoelectrochemical cocaine aptasensor based on an electropolymerized ruthenium-intercalator complex.. Electrochim. Acta. 219, 82–87.

Kazane, I., Gorgy K., Gondran C., Spinelli N., Zazoua A., Defrancq E., et al. (2016). Highly Sensitive Bisphenol-A Electrochemical Aptasensor Based on Poly(Pyrrole-Nitrilotriacetic Acid)-Aptamer Film.. Anal. Chem. (Washington, DC, United States). 88, 7268–7273.

Lecarme, L., Prado E., De Rache A., Nicolau-Travers M-L., Gellon G., Dejeu J., et al. (2016). Efficient Inhibition of Telomerase by Nickel-Salophen Complexes.. ChemMedChem. 11, 1133–1136.

Osypova, A., Thakar D., Dejeu J., Bonnet H., Van der Heyden A., Dubacheva G. V., et al. (2015). Sensor Based on Aptamer Folding to Detect Low-Molecular Weight Analytes.. Anal. Chem. (Washington, DC, United States). 87, 7566–7574.

Garnir, K., Estalayo-Adrian S., Lartia R., De Winter J., Defrancq E., Surin M., et al. (2015). Parameters influencing the photo-induced electron transfer from tryptophan-containing peptides to a RuII complex: a systematic study.. Faraday Discuss.. 185, 267–284.

Estalayo-Adrian, S., Lartia R., Meyer A., Vasseur J-J., Morvan F., & Defrancq E. (2015). Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides.. ChemistryOpen. 4, 169–173.

Sabater, L., Nicolau-Travers M-L., De Rache A., Prado E., Dejeu J., Bombarde O., et al. (2015). The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.. JBIC, J. Biol. Inorg. Chem.. 20, 729–738.

Yang, C., Spinelli N., Perrier S., Defrancq E., & Peyrin E.. (2015). Macrocyclic Host-Dye Reporter for Sensitive Sandwich-Type Fluorescent Aptamer Sensor.. Anal. Chem. (Washington, DC, United States). 87, 3139–3143.

Bonnet, R., Lavergne T., Gennaro B., Spinelli N., & Defrancq E. (2015). Construction of anti-parallel G-quadruplexes through sequential templated click.. Chem. Commun. (Cambridge, United Kingdom). 51, 4850–4853.

Sabater, L., Fang P-J., Chang C-F., De Rache A., Prado E., Dejeu J., et al. (2015). Cobalt(III)porphyrin to target G-quadruplex DNA.. Dalt. Trans.. 44, 3701–3707.

Marcelis, L., Surin M., Lartia R., Moucheron C., Defrancq E., & De Mesmaeker A.. Kirsch- (2014). Specificity of light-induced covalent adduct formation between RuII oligonucleotide conjugates and target sequences for gene silencing applications.. Eur. J. Inorg. Chem.. 2014, 3016–3022.

Stefan, L., Lavergne T., Spinelli N., Defrancq E., & Monchaud D.. (2014). Surface-immobilized DNAzyme-type biocatalysis.. Nanoscale. 6, 2693–2701.

Haddache, F., Le Goff A., Reuillard B., Gorgy K., Gondran C., Spinelli N., et al. (2014). Label-free photoelectrochemical detection of double-stranded HIV DNA by means of a metallointercalator-functionalized electrogenerated polymer.. Chem. - A Eur. J.. 20, 15555–15560.

Lecarme, L., Prado E., De Rache A., Nicolau-Travers M-L., Bonnet R., Van der Heyden A., et al. (2014). Interaction of Polycationic Ni(II)-Salophen Complexes with G-Quadruplex DNA.. Inorg. Chem.. 53, 12519–12531.

Xu, H., Gorgy K., Gondran C., Le Goff A., Spinelli N., Lopez C., et al. (2013). Label-free impedimetric thrombin sensor based on poly(pyrrole-nitrilotriacetic acid)-aptamer film. Biosensors and Bioelectronics. 41, 90 - 95.

Edupuganti, S. Ratna, Edupuganti O. Prakash, O'Kennedy R., Defrancq E., & Boullanger S.. (2013). Use of T-2 toxin-immobilized amine-activated beads as an efficient affinity purification matrix for the isolation of specific IgY.. J. Chromatogr. B Anal. Technol. Biomed. Life Sci.. 923-924, 98–101.

Gerard, V. A., Freeley M., Defrancq E., Fedorov A. V., & Gun'ko Y. K. (2013). Optical properties and in vitro biological studies of oligonucleotide-modified quantum dots.. J. Nanomater.. 463951, 11 pp..

Reschner, A., Shim Y. Ho, Dubois P., Delvenne P., Evrard B., Marcelis L., et al. (2013). Evaluation of a new biocompatible poly(N-(morpholino ethyl methacrylate))-based copolymer for the delivery of ruthenium oligonucleotides, targeting HPV16 E6 oncogene.. J. Biomed. Nanotechnol.. 9, 1432–1440.

Spinelli, N., Defrancq E., & Morvan F.. (2013). Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications.. Chem. Soc. Rev.. 42, 4557–4573.

Yao, W., Le Goff A., Spinelli N., Holzinger M., Diao G-W., Shan D., et al. (2013). Electrogenerated trisbipyridyl Ru(II)-/nitrilotriacetic-polypyrene copolymer for the easy fabrication of label-free photoelectrochemical immunosensor and aptasensor: Application to the determination of thrombin and anti-cholera toxin antibody.. Biosens. Bioelectron.. 42, 556–562.

Stefan, L., Duret D., Spinelli N., Defrancq E., & Monchaud D.. (2013). Closer to nature: an ATP-driven bioinspired catalytic oxidation process.. Chem. Commun. (Cambridge, United Kingdom). 49, 1500–1502.

Moreau, J., Dendane N., Schollhorn B., Spinelli N., Fave C., & Defrancq E. (2013). Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels.. Bioorg. Med. Chem. Lett.. 23, 955–958.

Keegan, G. L., Aherne D., Defrancq E., Gun'ko Y. K., & Kelly J. M. (2013). Oligonucleotide Functionalization of Hollow Triangular Gold Silver Alloy Nanoboxes.. J. Phys. Chem. C. 117, 669–676.

Le Gac, S., Surin M., Defrancq E., Moucheron C., & De Mesmaeker A.. Kirsch- (2013). What Are the Parameters Controlling Inter- vs. Intra-Strand DNA Photodamage with Ru-TAP Oligonucleotides?.. Eur. J. Inorg. Chem.. 2013, 208–216.

Jalit, Y., Gutierrez F. A., Dubacheva G. V., Goyer C., Guerente L., Defrancq E., et al. (2013). Characterization of a modified gold platform for the development of a label-free anti-thrombin aptasensor.. Biosens. Bioelectron.. 41, 424–429.

Reschner, A., Bontems S., Le Gac S., Lambermont J., Marcelis L., Defrancq E., et al. (2013). Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53.. Gene Ther.. 20, 435–443.

Bonnet, R., Murat P., Spinelli N., & Defrancq E. (2012). Click-click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures.. Chem. Commun. (Cambridge, United Kingdom). 48, 5992–5994.

Sallamand, C., Miscioscia A., Lartia R., & Defrancq E. (2012). Phosphorylating Reagent-Free Synthesis of 5'-Phosphate Oligonucleotides by Controlled Oxidative Degradation of Their 5'-End.. Org. Lett.. 14, 2030–2033.

Ghesquiere, J., Gauthier N., De Winter J., Gerbaux P., Moucheron C., Defrancq E., et al. (2012). Photocrosslinking between Peptide-Peptide or Peptide-Oligonucleotide by RuII-TAP Complexes.. Chem. - A Eur. J.. 18, 55–364, S355/1–S355/7.

Murat, P., Singh Y., & Defrancq E. (2011). Methods for investigating G-quadruplex DNA/ligand interactions.. Chem. Soc. Rev.. 40, 5293–5307.

Lartia, R., Murat P., Dumy P., & Defrancq E. (2011). Versatile Introduction of Azido Moiety into Oligonucleotides through Diazo Transfer Reaction.. Org. Lett.. 13, 5672–5675.

Romera, C., Bombarde O., Bonnet R., Gomez D., Dumy P., Calsou P., et al. (2011). Improvement of porphyrins for G-quadruplex DNA targeting.. Biochimie. 93, 1310–1317.

Gerard, V. A., Gun'ko Y. K., Defrancq E., & Govorov A. O. (2011). Plasmon-induced CD response of oligonucleotide-conjugated metal nanoparticles.. Chem. Commun. (Cambridge, United Kingdom). 47, 7383–7385.

Murat, P., Gennaro B., Garcia J., Spinelli N., Dumy P., & Defrancq E. (2011). The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water.. Chem. - A Eur. J.. 17, 5791–5795, S5791/1–S5791/21.

Tuccitto, N., Giamblanco N., Ghosh S., Spampinato V., Labbe P., Dumy P., et al. (2011). Controlled Density Patterning of Tolylterpyridine-Tagged Oligonucleotides.. Langmuir. 27, 8595–8599.

Baur, J., Gondran C., Holzinger M., Defrancq E., Perrot H., & Cosnier S. (2010). Label-free femtomolar detection of target DNA by impedimetric DNA sensor based on poly(pyrrole-nitrilotriacetic acid) film.. Anal. Chem. (Washington, DC, United States). 82, 1066–1072.

Ghosh, S., & Defrancq E. (2010). Metal-Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays.. Chem. - A Eur. J.. 16, 12780–12787.

Rebarz, M., Ghesquiere J., Boisdenghien A., Defrancq E., Moucheron C., & De Mesmaeker A.. Kirsch- (2010). Photoinduced Electron Transfer from Tryptophan to RuIITAP Complexes: The Primary Process for Photo-Cross-Linking with Oligopeptides.. Inorg. Chem.. 49, 10867–10874.

Le Gac, S., Foucart M., Gerbaux P., Defrancq E., Moucheron C., & De Mesmaeker A.. Kirsch- (2010). Photo-reactive RuII-oligonucleotide conjugates: influence of an intercalating ligand on the inter- and intra-strand photo-ligation processes.. Dalt. Trans.. 39, 9672–9683.

Singh, Y., Murat P., & Defrancq E. (2010). Recent developments in oligonucleotide conjugation.. Chem. Soc. Rev.. 39, 2054–2070.

Murat, P., Bonnet R., Van der Heyden A., Spinelli N., Labbe P., Monchaud D., et al. (2010). Template-Assembled Synthetic G-Quadruplex (TASQ): A Useful System for Investigating the Interactions of Ligands with Constrained Quadruplex Topologies.. Chem. - A Eur. J.. 16, 6106–6114, S6106/1–S6106/16.

Meyer, A., Spinelli N., Dumy P., Vasseur J-J., Morvan F., & Defrancq E. (2010). Oligonucleotide Sequential Bis-Conjugation via Click-Oxime and Click-Huisgen Procedures.. J. Org. Chem.. 75, 3927–3930.

Renaudet, O., Garcia J., Boturyn D., Spinelli N., Defrancq E., Labbe P., et al. (2010). Molecular engineering of biomolecules for nanobio-sciences.. Int. J. Nanotechnol.. 7, 738–752.

Rickling, S., Ghisdavu L., Pierard F., Gerbaux P., Surin M., Murat P., et al. (2010). A Rigid Dinuclear Ruthenium(II) Complex as an Efficient Photoactive Agent for Bridging Two Guanine Bases of a Duplex or Quadruplex Oligonucleotide.. Chem. - A Eur. J.. 16, 3951–3961, S3951/1–S3951/9.

Deroo, S., Le Gac S., Ghosh S., Villien M., Gerbaux P., Defrancq E., et al. (2009). Oligonucleotide duplexes with tethered photoreactive ruthenium(II) complexes: influence of the ligands and their linker on the photoinduced electron transfer and crosslinking processes of the two strands.. Eur. J. Inorg. Chem.. 524–532.

Murat, P., Spinelli N., Dumy P., & Defrancq E. (2009). Efficient conjugation of oligonucleotides through aromatic oxime formation.. Bioorg. Med. Chem. Lett.. 19, 6534–6537.

Ghizdavu, L., Pierard F., Rickling S., Aury S., Surin M., Beljonne D., et al. (2009). Oxidizing Ru(II) Complexes as Irreversible and Specific Photocrosslinking Agents of Oligonucleotide Duplexes.. Inorg. Chem.. 48, 10988–10994.

Ghosh, S., Pignot-Paintrand I., Dumy P., & Defrancq E. (2009). Design and synthesis of novel hybrid metal complex-DNA conjugates: Key building blocks for multimetallic linear DNA nanoarrays.. Org. Biomol. Chem.. 7, 2729–2737.

Le Gac, S., Rickling S., Gerbaux P., Defrancq E., Moucheron C., & De Mesmaeker A.. Kirsch- (2009). A photoreactive ruthenium(II) complex tethered to a guanine-containing oligonucleotide: A biomolecular tool that behaves as a "Seppuku Molecule".. Angew. Chemie, Int. Ed.. 48, 1122–1125.

Murat, P., Cressend D., Spinelli N., Van der Heyden A., Labbe P., Dumy P., et al. (2008). A novel conformationally constrained parallel G quadruplex.. ChemBioChem. 9, 2588–2591.

Dendane, N., Hoang A., Renaudet O., Vinet F., Dumy P., & Defrancq E. (2008). Surface patterning of (bio)molecules onto the inner wall of fused-silica capillary tubes.. Lab Chip. 8, 2161–2163.

Boturyn, D., Defrancq E., Dolphin G. T., Garcia J., Labbe P., Renaudet O., et al. (2008). RAFT Nano-constructs: surfing to biological applications.. J. Pept. Sci.. 14, 224–240.

Spinelli, N., Singh Y., Defrancq E., & Dumy P. (2007). Aldehydic Oligonucleotide: A Key Intermediate for the Preparation of Oligonucleotide Conjugates Through Oxime Bond Formation.. Nucleosides. Nucleotides Nucleic Acids. 26, 883–887.

Deroo, S., Toncheva V., Defrancq E., Moucheron C., Schacht E., & De Mesmaeker A.. Kirsch- (2007). Photo-Cross-Linking between Polymers Derivatized with Photoreactive Ruthenium-1,4,5,8-Tetraazaphenanthrene Complexes and Guanine-Containing Oligonucleotides.. Biomacromolecules. 8, 3503–3510.

Dendane, N., Hoang A., Guillard L., Defrancq E., Vinet F., & Dumy P. (2007). Efficient Surface Patterning of Oligonucleotides Inside a Glass Capillary through Oxime Bond Formation.. Bioconjug. Chem.. 18, 671–676.

Spinelli, N., Edupuganti O. Prakash, Defrancq E., & Dumy P. (2007). New Solid Support for the Synthesis of 3'-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation.. Org. Lett.. 9, 219–222.

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0456520830

Eric.Defrancq@univ-grenoble-alpes.fr

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Département de chimie moléculaire

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