CATHERINE BELLE
Directrice de recherche (CNRS)
Affiliation
Centre national de la recherche scientifique
Équipe de recherche
DCM-CIRE
Domaines de recherche
Bio-Inorganic Chemistry, Bio-inspired catalysis, recognition and inhibition
Disciplines scientifiques
Chimie organique, minérale, industrielle
Habilitation à diriger des recherches
Responsabilités
-2016-present: Team leader of the thematic group "Reactivity and Mechanism of Bio-Inspired Complexes"
-2014-present: Scientific Board member of the Institute of Metals in Biology od Grenoble (IMBG)
-2009-present: Scientific Manager of the ICMG (FR 23107) X-Ray platform
-2014-present: Scientific Board member of the Institute of Metals in Biology od Grenoble (IMBG)
-2009-present: Scientific Manager of the ICMG (FR 23107) X-Ray platform
Van der Heyden, A., Chanthavong P., Angles-Cano E., Bonnet H., Dejeu J., Cras A., et al.
(2023). Grafted dinuclear zinc complexes for selective recognition of phosphatidylserine: Application to the capture of extracellular membrane microvesicles.
Journal of Inorganic Biochemistry. 239, 112065.
Buitrago, E., Faure C., Carotti M., Bergantino E., Hardré R., Maresca M., et al.
(2023). Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase.
European Journal of Medicinal Chemistry. 248, 115090.
Faure, C., d’Hardemare A. du Mouline, Jamet H., Belle C., Bergantino E., Bubacco L., et al.
(2023). Transition State Analogue Molecules as Mechanistic Tools and Inhibitors for Tyrosinase.
Copper Bioinorganic Chemistry. 45-80.
Faure, C., Jamet H., Belle C., & Du Moulinet D'Hardemare A.
(2020). Exploring Coumarins Reduction: NaBH4/MeOH versus Nickel Boride Generated In Situ..
ChemistrySelect. 5, 14735-14740.
Bacher, F., Isaac J. A., Philouze C., Flot D., Thibon-Pourret A., & Belle C.
(2020). Synthesis of unsymmetrical 1,8-naphthyridine-based ligands for the assembly of tri-and tetra-nuclear copper(ii) complexes.
New J. Chem.. 44, 16713-16720.
Bijelic, A., Rompel A., & Belle C.
(2019). Tyrosinases: Enzymes, Models and Related Applications.
Bioinspired Chemistry. 155-183.
Isaac, J. A., Thibon-Pourret A., Durand A., Philouze C., Le Poul N., & Belle C.
(2019). High-valence CuIICuIII species in action: demonstration of aliphatic C-H bond activation at room temperature.
Chem. Commun.. 55, 12711-12714.
Isaac, J.. A., Mansour A.-T.., David R., Kochem A.., Philouze C., Demeshko S.., et al.
(2018). Tetranuclear and dinuclear phenoxido bridged copper complexes based on unsymmetrical thiosemicarbazone ligands.
Dalt. Trans.. 47, 9665-9676.
Thibon-Pourret, A., Gennarini F., David R., Isaac J. A., Lopez I., Gellon G., et al.
(2018). Effect of Monoelectronic Oxidation of an Unsymmetrical Phenoxido-Hydroxido Bridged Dicopper(II) Complex.
Inorganic Chemistry. 57, 12364-12375.
Gennarini, F., Kochem A., Isaac J., Mansour A-T., Lopez I., Le Mest Y., et al.
(2018). Effect of ligand exchange on the one-electron oxidation process of alkoxo or phenoxo bridged binuclear copper(II) complexes.
Inorganica Chimica Acta. 481, 113 - 119.
Gennarini, F., David R., Lopez I., Le Mest Y., Reglier M., Belle C., et al.
(2017). Influence of Asymmetry on the Redox Properties of Phenoxo- and Hydroxo-Bridged Dicopper Complexes: Spectroelectrochemical and Theoretical Studies..
Inorg. Chem.. 56, 7707–7719.
Haudecoeur, R., Carotti M., Gouron A., Maresca M., Buitrago E., Hardre R., et al.
(2017). 2-Hydroxypyridine-N-oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors..
ACS Med. Chem. Lett.. 8, 55–60.
Buitrago, E., Hardre R., Haudecoeur R., Jamet H., Belle C., Boumendjel A., et al.
(2016). Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?..
Curr. Top. Med. Chem. (Sharjah, United Arab Emirates). 16, 3033–3047.
Isaac, J., Gennarini F., Lopez I., Thibon-Pourret A., David R., Gellon G., et al.
(2016). Room-Temperature Characterization of a Mixed-Valent u-Hydroxodicopper(II,III) Complex..
Inorg. Chem.. 55, 8263–8266.
Buitrago, E., Vuillamy A., Boumendjel A., Yi W., Gellon G., Hardre R., et al.
(2014). Exploring the Interaction of N/S Compounds with a Dicopper Center: Tyrosinase Inhibition and Model Studies..
Inorg. Chem.. 53, 12848–12858.
Bochot, C., Gouron A., Bubacco L., Milet A., Philouze C., Reglier M., et al.
(2014). Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations..
Chem. Commun. (Cambridge, United Kingdom). 50, 308–310.
Haudecoeur, R., Gouron A., Dubois C., Jamet H., Lightbody M., Hardre R., et al.
(2014). Investigation of Binding-Site Homology between Mushroom and Bacterial Tyrosinases by Using Aurones as Effectors..
ChemBioChem. 15, 1325–1333.
Bochot, C., Favre E., Dubois C., Baptiste B., Bubacco L., Carrupt P-A., et al.
(2013). Unsymmetrical Binding Modes of the HOPNO Inhibitor of Tyrosinase: From Model Complexes to the Enzyme..
Chem. - A Eur. J.. 19, 3655–3664.
Rammal, W., Selmeczi K., Philouze C., Saint-Aman E., Pierre J-L., & Belle C.
(2013). Thiomethyl Substituted Dicopper Complexes: Attempts to Reproduce the Asymmetry of the Active Site from Type 3 Copper Enzymes..
Zeitschrift fuer Anorg. und Allg. Chemie. 639, 1477–1482.
Dubois, C., Haudecoeur R., Orio M., Belle C., Bochot C., Boumendjel A., et al.
(2012). Versatile Effects of Aurone Structure on Mushroom Tyrosinase Activity..
ChemBioChem. 13, 559–565.
Yi, W., Dubois C., Yahiaoui S., Haudecoeur R., Belle C., Song H., et al.
(2011). Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase..
Eur. J. Med. Chem.. 46, 4330–4335.
Haudecoeur, R., Ahmed-Belkacem A., Yi W., Fortune A., Brillet R., Belle C., et al.
(2011). Discovery of Naturally Occurring Aurones That Are Potent Allosteric Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase..
J. Med. Chem.. 54, 5395–5402.
Durot, S., Hossain L. H., Hamman S., Jamet H., Orio M., Gautier-Luneau I., et al.
(2010). Separation of Geometric Isomers of a Dicopper Complex by Using a 19F-Labeled Ligand: Dynamics, Structures, and DFT Calculations..
Inorg. Chem.. 49, 7832–7840.
Peyroux, E., Ghattas W., Hardre R., Giorgi M., Faure B., A Simaan J., et al.
(2009). Binding of 2-Hydroxypyridine-N-oxide on Dicopper(II) Centers: Insights into Tyrosinase Inhibition Mechanism by Transition-State Analogs..
Inorg. Chem.. 48, 10874–10876.
Rammal, W., Jamet H., Philouze C., Pierre J-L., Saint-Aman E., & Belle C.
(2009). Structural and redox properties in thioether-based (N/S) copper(II/I) complexes: Experimental and theoretical investigations..
Inorganica Chim. Acta. 362, 2321–2326.
Belle, C., Béguin C., Hamman S., & Pierre J-L..
(2009). 19F NMR: An underused efficient probe for paramagnetic metal centers in bioinorganic solution chemistry..
Coord. Chem. Rev.. 253, 963–976.
Selmeczi, K., Michel C., Milet A., Gautier-Luneau I., Philouze C., Pierre J-L., et al.
(2007). Structural, kinetic, and theoretical studies on models of the zinc-containing phosphodiesterase active center: medium-dependent reaction mechanisms..
Chem. - A Eur. J.. 13, 9093–9106.
Koval, I. A., Akhideno H., Tanase S., Belle C., Duboc C., Saint-Aman E., et al.
(2007). Changes in magnetic properties from solid state to solution in a trinuclear linear copper(II) complex..
New J. Chem.. 31, 512–518.
Belle, C., Selmeczi K., Torelli S., & Pierre J-L..
(2007). Chemical tools for mechanistic studies related to catechol oxidase activity..
Comptes Rendus Chim.. 10, 271–283.
Rammal, W., Belle C., Béguin C., Duboc C., Philouze C., Pierre J-L., et al.
(2006). Multifrequency EPR and Redox Reactivity Investigations of a Bis(μ-thiolato)-dicopper(II,II) Complex..
Inorg. Chem.. 45, 10355–10362.
Koval, I. A., Gamez P., Belle C., Selmeczi K., & Reedijk J..
(2006). Synthetic models of the active site of catechol oxidase: Mechanistic studies..
Chem. Soc. Rev.. 35, 814–840.
Koval, I. A., Selmeczi K., Belle C., Philouze C., Saint-Aman E., Gautier-Luneau I., et al.
(2006). Catecholase activity of a copper(II) complex with a macrocyclic ligand: unraveling catalytic mechanisms..
Chem. - A Eur. J.. 12, 6138–6150.
Education:
1985: Chemical Engineering Degree, research and development, Marseille
1988: PhD, Univ. Aix-Marseille III (Pr. R. Gallo)
2003 : Habilitation à Diriger les Recherches – Univ. J. Fourier, Grenoble I
Research approaches include: a) design and syntheses of ligands allowing formation of appropriate complexes, b) synthesis and purification of such compound, c) structural and physical properties using IR, UV-Vis, (1H, 19F, 31P) paramagnetic NMR, X-ray crystallography, EPR, kinetics…, ) d)reactivity and mechanistic investigations such as in reversible O2-binding by copper complexes and oxidation of substrates, e) development of inhibitors that better target the metal active site such in tyrosinase using fundamental recognition properties of inorganic chemistry.
1985: Chemical Engineering Degree, research and development, Marseille
1988: PhD, Univ. Aix-Marseille III (Pr. R. Gallo)
2003 : Habilitation à Diriger les Recherches – Univ. J. Fourier, Grenoble I
Research approaches include: a) design and syntheses of ligands allowing formation of appropriate complexes, b) synthesis and purification of such compound, c) structural and physical properties using IR, UV-Vis, (1H, 19F, 31P) paramagnetic NMR, X-ray crystallography, EPR, kinetics…, ) d)reactivity and mechanistic investigations such as in reversible O2-binding by copper complexes and oxidation of substrates, e) development of inhibitors that better target the metal active site such in tyrosinase using fundamental recognition properties of inorganic chemistry.
