Département de chimie moléculaire

A simple and rapid photoelectrochem. (PEC) sensor is developed for the label-free detection of a phosphoprotein ($\alpha$-casein) based on a zirconium based porphyrinic metal-org. framework (MOF), PCN-222, which exhibits an enhanced photocurrent response towards dopamine under the O2-satd. aq. media. In this work, in terms of PEC measurements and cyclic voltammetry, the PEC behaviors of PCN-222 in aq. media were thoroughly investigated for the first time. Addnl., in the virtue of the steric hindrance effect from the coordination of the phosphate groups and inorg. Zr-O clusters as binding sites in PCN-222, this biosensor shows high sensitivity for detecting $\alpha$-casein and the limit of detection (LOD) is estd. to be 0.13 $μ$g mL-1. Moreover, the proposed method provides a promising platform for clinic diagnostic and therapeutics. [on SciFinder(R)]