Département de chimie moléculaire

Electropolymeric film of pyrrole-alkylammonium (A2) cationic surfactant and multi-wall C nanotubes (MWCNTs) composite was firstly used to absorb Fe(CN)63-/4- ions as electrochem. markers to develop amperometric assay for electrochem. inactive heparin. The electrochem. behaviors of the modified Pt electrodes were characterized by cyclic voltammetry and electrochem. impedance spectroscopy. A quite stable and well-defined redox peaks of the confined Fe(CN)63-/4- with neg. shifted potentials compared to the Fe(CN)63-/4$\backslash$- in aq. soln. were obsd. at Fe(CN)63-/4-/polyA2-MWCNTs/Pt. Importantly, the ion exchange of the small anions, Fe(CN)63-/4- by polyanions, heparin at polyA2-MWCNTs films was obsd. Thereafter, an amperometric assay for heparin based on anion exchange at Fe(CN)63-/4-/polyA2-MWCNTs/Pt was developed. The linear range to detect heparin with differential pulse voltammetry (DPV) is 0.1-8.0 $μ$M with the limit of detection of 0.1 $μ$M. [on SciFinder(R)]