The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water.
The authors have designed and synthesized two original architectures based on a cyclodecapeptide scaffold to form G-quartets in water without the addn. of cations. In addn. to the entropically driven formation of the G-quartet (formed by coplanar arrangement of four Hoogsteen-paired guanine bases), the synthetic strategy takes advantage of the triazole linkers (prepd. via click chem.) for further stabilization of the G-quartet motif. Preliminary studies have shown that compd. 3 in the presence of free guanosine monophosphate (GMP) allows the nucleation of G-quartet aggregates. The designed architectures display a free amino moiety on the lower face of the cyclodecapeptide scaffold; this moiety can be used for the functionalization of a surface and the growth control of quartet fibers on surface. These approaches may allow studies and understanding of complex phenomena, such as the self-assembly of nucleobases in aq. media. [on SciFinder(R)]
Références
- Titre
- The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water.
- Type de publication
- Article de revue
- Année de publication
- 2011
- Auteurs
- Murat, Pierre, Gennaro Béatrice, Garcia Julian, Spinelli Nicolas, Dumy Pascal, and Defrancq Eric
- Revue
- Chem. - A Eur. J.
- Volume
- 17
- Pagination
- 5791–5795, S5791/1–S5791/21
- ISSN
- 0947-6539
Soumis le 12 avril 2018