The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water.

The authors have designed and synthesized two original architectures based on a cyclodecapeptide scaffold to form G-quartets in water without the addn. of cations. In addn. to the entropically driven formation of the G-quartet (formed by coplanar arrangement of four Hoogsteen-paired guanine bases), the synthetic strategy takes advantage of the triazole linkers (prepd. via click chem.) for further stabilization of the G-quartet motif. Preliminary studies have shown that compd. 3 in the presence of free guanosine monophosphate (GMP) allows the nucleation of G-quartet aggregates. The designed architectures display a free amino moiety on the lower face of the cyclodecapeptide scaffold; this moiety can be used for the functionalization of a surface and the growth control of quartet fibers on surface. These approaches may allow studies and understanding of complex phenomena, such as the self-assembly of nucleobases in aq. media. [on SciFinder(R)]

Références

Titre
The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water.
Type de publication
Article de revue
Année de publication
2011
Revue
Chem. - A Eur. J.
Volume
17
Pagination
5791–5795, S5791/1–S5791/21
ISSN
0947-6539
Soumis le 12 avril 2018