Département de chimie moléculaire

The authors have designed and synthesized two original architectures based on a cyclodecapeptide scaffold to form G-quartets in water without the addn. of cations. In addn. to the entropically driven formation of the G-quartet (formed by coplanar arrangement of four Hoogsteen-paired guanine bases), the synthetic strategy takes advantage of the triazole linkers (prepd. via click chem.) for further stabilization of the G-quartet motif. Preliminary studies have shown that compd. 3 in the presence of free guanosine monophosphate (GMP) allows the nucleation of G-quartet aggregates. The designed architectures display a free amino moiety on the lower face of the cyclodecapeptide scaffold; this moiety can be used for the functionalization of a surface and the growth control of quartet fibers on surface. These approaches may allow studies and understanding of complex phenomena, such as the self-assembly of nucleobases in aq. media. [on SciFinder(R)]