Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.

Aminoacridine derivs. display interesting chem. and biol. properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labeled analog allows the study of cell distribution using two innovative, complementary and powerful techniques, real time fluorescence microscopy and dynamic secondary ion mass spectrometry (SIMS). All the data point to lysosomal localization of the active mol. [on SciFinder(R)]

Références

Titre
Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
Type de publication
Article de revue
Année de publication
2009
Revue
Eur. J. Med. Chem.
Volume
44
Pagination
4758–4763
ISSN
0223-5234
Soumis le 12 avril 2018