Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
Aminoacridine derivs. display interesting chem. and biol. properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labeled analog allows the study of cell distribution using two innovative, complementary and powerful techniques, real time fluorescence microscopy and dynamic secondary ion mass spectrometry (SIMS). All the data point to lysosomal localization of the active mol. [on SciFinder(R)]
Références
- Titre
- Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
- Type de publication
- Article de revue
- Année de publication
- 2009
- Auteurs
- Peixoto, Paul, Zeghida Walid, Carrez Daniele, Di Wu Ting-, Wattez Nicole, Croisy Alain, Demeunynck Martine, Guerquin-Kern Jean-Luc, and Lansiaux Amelie.
- Revue
- Eur. J. Med. Chem.
- Volume
- 44
- Pagination
- 4758–4763
- ISSN
- 0223-5234
Soumis le 12 avril 2018