Totally diastereoselective addition of aryl Grignard reagents to the nitrone-based chiral glycine equivalent MiPNO.
The reaction of the chiral nitrone MiPNO (2-isopropyl-2,3-dimethyl-1-oxy-2,3-dihydro-imidazol-4-one) with Grignard reagents is totally diastereoselective. Using simple and functionalized arylmagnesium reagents, enantiopure hydroxylamines were obtained in fair to good yields, which in turn could be easily transformed into new chiral keto nitrones. The prepn. of enantiopure L-phenylglycine derivs. is also described. [on SciFinder(R)]
Références
- Titre
- Totally diastereoselective addition of aryl Grignard reagents to the nitrone-based chiral glycine equivalent MiPNO.
- Type de publication
- Article de revue
- Année de publication
- 2011
- Auteurs
- Thiverny, Maryse, Farran Daniel, Philouze Christian, Blandin Véronique, and Chavant Pierre-Yves
- Revue
- Tetrahedron: Asymmetry
- Volume
- 22
- Pagination
- 1274–1281
- ISSN
- 0957-4166
Soumis le 12 avril 2018