Département de chimie moléculaire

{The synthesis of four natural bis(indole) alkaloids of the topsentin class is described. Their bis(indole) $\alpha$-carbonylimidazoline and subsequently bis(indole) $\alpha$-carbonylimidazole moieties have been built via the condensation between indolic $\alpha$-ketothioimidate salts and 1-(indol-3'-yl)-1,2-diaminoethane. This is the first total synthesis of compds. isobromodeoxytopsentin I (double bond