Total Synthesis of Marine Sponge Bis(indole) Alkaloids of the Topsentin Class.

{The synthesis of four natural bis(indole) alkaloids of the topsentin class is described. Their bis(indole) $\alpha$-carbonylimidazoline and subsequently bis(indole) $\alpha$-carbonylimidazole moieties have been built via the condensation between indolic $\alpha$-ketothioimidate salts and 1-(indol-3'-yl)-1,2-diaminoethane. This is the first total synthesis of compds. isobromodeoxytopsentin I (double bond

Références

Titre
Total Synthesis of Marine Sponge Bis(indole) Alkaloids of the Topsentin Class.
Type de publication
Article de revue
Année de publication
2007
Revue
J. Org. Chem.
Volume
72
Pagination
3972–3975
ISSN
0022-3263
Soumis le 12 avril 2018