Total synthesis of (±)-17-norcamptothecin, a novel E-ring modified camptothecin.
The first total synthesis of (±)-17-norcamptothecin (I), a novel camptothecin analog possessing an $\alpha$-hydroxy-$\gamma$-lactone E-ring, has been accomplished by using a short and flexible route. The stability of this new compd. in aq. medium has been evaluated through fluorescence spectroscopy. [on SciFinder(R)]
Références
- Titre
- Total synthesis of (±)-17-norcamptothecin, a novel E-ring modified camptothecin.
- Type de publication
- Article de revue
- Année de publication
- 2010
- Auteurs
- Devert, Marie, Sabot Cyrille, Giboreau Pascale, Constant Jean-François, Greene Andrew E., and Kanazawa Alice
- Revue
- Tetrahedron
- Volume
- 66
- Pagination
- 7227–7231
- ISSN
- 0040-4020
- Mots-clés
- norcamptothecin total synthesis
Soumis le 12 avril 2018