Département de chimie moléculaire

Total syntheses of six brominated marine sponge bis(indole) alkaloids of the hamacanthin, spongotine, and topsentin classes are described. Retrosynthetic anal. shows that their structures all include the 1-(6'-bromoindol-3'-yl)-1,2-diaminoethane unit I. This key moiety has been prepd. from a brominated indolic N-hydroxylamine via synthetic intermediate II. [on SciFinder(R)]