Total Syntheses of Brominated Marine Sponge Alkaloids.

Total syntheses of six brominated marine sponge bis(indole) alkaloids of the hamacanthin, spongotine, and topsentin classes are described. Retrosynthetic anal. shows that their structures all include the 1-(6'-bromoindol-3'-yl)-1,2-diaminoethane unit I. This key moiety has been prepd. from a brominated indolic N-hydroxylamine via synthetic intermediate II. [on SciFinder(R)]

Références

Titre
Total Syntheses of Brominated Marine Sponge Alkaloids.
Type de publication
Article de revue
Année de publication
2007
Revue
Org. Lett.
Volume
9
Pagination
3761–3764
ISSN
1523-7060
Soumis le 12 avril 2018