Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones.

Access to chiral polysubstituted cyclobutanones by [2+2]-cycloaddn. of ketenes with chiral acyclic enol ethers is reported. A wide variety of easily accessible di- and monosubstituted ketenes were found to react with a very high degree of stereoselectivity with chiral, stericol-derived, acyclic enol ethers. This combination of simple reagents provides straightforward entry to highly substituted enantioenriched cyclobutanones, e.g., I.

Références

Titre
Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones.
Type de publication
Article de revue
Année de publication
2016
Revue
Org. Lett.
Volume
18
Pagination
2824–2827
ISSN
1523-7052
Soumis le 12 avril 2018