Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones.
Access to chiral polysubstituted cyclobutanones by [2+2]-cycloaddn. of ketenes with chiral acyclic enol ethers is reported. A wide variety of easily accessible di- and monosubstituted ketenes were found to react with a very high degree of stereoselectivity with chiral, stericol-derived, acyclic enol ethers. This combination of simple reagents provides straightforward entry to highly substituted enantioenriched cyclobutanones, e.g., I.
Références
- Titre
- Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones.
- Type de publication
- Article de revue
- Année de publication
- 2016
- Auteurs
- Rullière, Pauline, Grisel Julien, Poittevin Clément, Cividino Pascale, Carret Sébastien, and Poisson Jean-François
- Revue
- Org. Lett.
- Volume
- 18
- Pagination
- 2824–2827
- ISSN
- 1523-7052
Soumis le 12 avril 2018