Département de chimie moléculaire

A review. Synthetic iron chelators (siderophores mimics) are of paramount interest as clin. iron removal agents (iron overload is one of the most common poisoning) and water-sol. iron complexes can be used to alleviate iron deficiency in plants. Moreover, some addnl. properties may be needed for a precise function (as examples, probes for studying metal transport, diagnostic tools, agent suited for vectorisation...). The authors described in this review the org. syntheses of selected typical examples from the authors' works such as: (a) amphiphilic chelators based on catechol groups; (b) mixed ligands based on catechol and quinoline groups; (c) quinolobactin, a natural siderophore; and (d) oxinobactin, a biomimetic synthetic analog of enterobactin involving 8-hydroxyquinoline chelating subunits. [on SciFinder(R)]