Synthesis of new calix[4]arene based chiral ligands bearing beta-amino alcohol groups and their application in asymmetric transfer hydrogenation
A new series of chiral calix[4]arenes bearing beta-amino alcohol groups have been synthesised. The crucial steps consist of the binding of glycidyl groups on the lower rim of the calix[4]arenas, followed by their regioselective opening with amines. These ligands were successfully tested in an asymmetric transfer hydrogenation. The best results (conversion max=97% and ee max=87%) were obtained using calix[4]arene mono-functionalised ligands. These results are the best ones obtained using calixarene based ligands in asymmetric catalysis.
Références
- Titre
- Synthesis of new calix[4]arene based chiral ligands bearing beta-amino alcohol groups and their application in asymmetric transfer hydrogenation
- Type de publication
- Article de revue
- Année de publication
- 2007
- Auteurs
- Quintard, Adrien, Darbost Ulrich, Vocanson Francis, Pellet-Rostaing Stephane, and Lemaire Marc
- Revue
- Tetrahedron: Asymmetry
- Volume
- 18
- Pagination
- 1926–1933
- ISSN
- 0957-4166
Soumis le 7 septembre 2022