Département de chimie moléculaire

Synthetic heteroglycoclusters are being subjected to increasing interest due to their potential to serve as selective ligands for carbohydrate-binding proteins. In this paper, the authors describe an expedient strategy to prep. cyclopeptides displaying well-defined distributions and combinations of carbohydrates. By using both oxime ligation and copper(I)-catalyzed alkyne-azide cycloaddn., two series of compds. bearing binary combinations of $\alpha$-Man, $\alpha$-Fuc or $\beta$-Lac in an overall tetravalent presentation, and either 2:2 or 3:1 relative proportions, have been prepd. [on SciFinder(R)]