Département de chimie moléculaire

A new series of tetravalent glycocyclopeptides has been prepd. using the copper(I)-catalyzed alkyne-azide cycloaddn. (CuAAC). When compared with our oximation procedure previously described, we found that the CuAAC strategy led to glycoclusters with similar yield and purity. In addn., the binding properties of these two series of glycoclusters (i.e., with oxime or triazole linkage) were studied with several lectins. Interestingly, while no difference of binding was obsd. with the mannose-specific lectin from Canavalia ensiformis (ConA), the compd. displaying $\alpha$Fuc through oxime linkage has revealed a significant binding improvement with the fucose-specific lectin from Ulex europaeus (UEA-I). [on SciFinder(R)]