Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.

A collection of 3-substituted indole derivs. was prepd. using nucleophilic addn. of indoles to nitrones. The compds. were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic mols. inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L. [on SciFinder(R)]

Références

Titre
Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.
Type de publication
Article de revue
Année de publication
2011
Revue
Bioorg. Med. Chem.
Volume
19
Pagination
3204–3215
ISSN
0968-0896
Soumis le 12 avril 2018