Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels.

Oxime bond formation has been applied to the prepn. of oligonucleotides labeled with electrochem. ferrocene and viologen labels. Aminooxy functionalized ferrocene and viologen derivs. were prepd. by a straightforward route and efficiently conjugated with aldehyde contg. oligonucleotides either at 3' or 5' end. Both labels were found to not disturb the recognition properties of the oligonucleotide. The versatility of the method was further demonstrated by prepg. bi-functionalized conjugates with a disulfide at 3' end and an electrochem. label at 5' end. [on SciFinder(R)]

Références

Titre
Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels.
Type de publication
Article de revue
Année de publication
2013
Revue
Bioorg. Med. Chem. Lett.
Volume
23
Pagination
955–958
ISSN
0960-894X
Soumis le 12 avril 2018