Département de chimie moléculaire

Oxime bond formation has been applied to the prepn. of oligonucleotides labeled with electrochem. ferrocene and viologen labels. Aminooxy functionalized ferrocene and viologen derivs. were prepd. by a straightforward route and efficiently conjugated with aldehyde contg. oligonucleotides either at 3' or 5' end. Both labels were found to not disturb the recognition properties of the oligonucleotide. The versatility of the method was further demonstrated by prepg. bi-functionalized conjugates with a disulfide at 3' end and an electrochem. label at 5' end. [on SciFinder(R)]