Département de chimie moléculaire

Ketonitrone I was prepd. from D-fructose as an inexpensive starting material and was used in a stereoselective synthesis of 1-deoxymannojirimycin (DMJ), of its previously unknown N-hydroxy analog II, and of the polyhydroxylated ketonitrone III. The latter were assayed as potential glycosidase inhibitors on a panel of 13 selected purified enzymes. Disappointingly, the polyhydroxylated nitrone III inhibited none of these enzymes. However, II exhibited a moderate and non-selective activity toward the snail $\beta$-mannosidase EC 3.2.1.25. [on SciFinder(R)]