Ruthenacycles and Iridacycles as Catalysts for Asymmetric Transfer Hydrogenation and Racemisation.

Ruthenacycles, which are easily prepd. in a single step by reaction between enantiopure arom. amines and [Ru(arene)Cl2]2 in the presence of NaOH and KPF6, are very good asym. transfer hydrogenation catalysts. A range of arom. ketones were reduced using isopropanol in good yields with ee's up to 98{%}. Iridacycles, which are prepd. in similar fashion from [IrCp*Cl2]2 are excellent catalysts for the racemization of secondary alcs. and chlorohydrins at room temp. This allowed the development of a new dynamic kinetic resoln. of chlorohydrins to the enantiopure epoxides in up to 90{%} yield and 98{%} enantiomeric excess (ee) using a mutant of the enzyme Haloalc. dehalogenase C and an iridacycle as racemization catalyst. [on SciFinder(R)]

Références

Titre
Ruthenacycles and Iridacycles as Catalysts for Asymmetric Transfer Hydrogenation and Racemisation.
Type de publication
Article de revue
Année de publication
2010
Revue
Top. Catal.
Volume
53
Pagination
1002–1008
ISSN
1022-5528
Soumis le 12 avril 2018