Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression.

Two tetravalent architectures, glycocalix and the RAFT 9 (I), presenting four residues of a GM-3 ganglioside lactone mimetic, target the host compartment of melanoma and significantly abrogate the effect induced by cancer-assocd. fibroblasts (CAFs) contact + hypoxia in the motility and invasiveness of tumor cells. The data reported support the involvement of glycosphingolipids (GSLs) in hypoxia and show an interesting role played by compd. I in targeting melanoma cells thereby interfering with melanoma progression. The unprecedented findings reported for the glycocluster I may contribute to the understanding of the crit. and complex interactions between tumor cells and their local environment paving the way for new therapeutic agents. [on SciFinder(R)]

Références

Titre
Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression.
Type de publication
Article de revue
Année de publication
2016
Revue
ACS Med. Chem. Lett.
Volume
7
Pagination
28–33
ISSN
1948-5875
Soumis le 12 avril 2018