Département de chimie moléculaire

Melanin play a major role in human skin protection and their biosynthesis is vital. Due to their color, they contribute to the skin pigmentation. Tyrosinase is a key enzyme involved in the first stage of melanin biosynthesis, it catalyzes the transformation of tyrosine into L-dopaquinone. The aim of the present study was to study mols. able to inhibit tyrosinase to be used in treating depigmentation-related disorders. In this study, we targeted arylthiosemicarbazone analogs with the aim to contribute to the identification of the optimal aryl ring to be linked to the thiosemicarbazone moiety. The biol. activity was evaluated on com. mushroom tyrosinase which was purified prior use. The results demonstrated that several of our compds. (1a-h, 1j, 1r and 5) had more potent inhibitory activities than kojic acid which was used as the ref. inhibitor. [on SciFinder(R)]