Département de chimie moléculaire

A nanometer scale redox active biomol. architecture has been successfully synthesized through an efficient chemoselective oxime based coupling between ferrocenyl groups and a regioselectively addressable cyclodecapeptide. This mol. tool exhibits electronic, structural, and chem. properties driven by the biomimetic recognition activity of the polypeptide skeleton assocd. to the well-defined electrochem. activity of metallocenyl probes. Biomol. materials obtained by confinement of the redox cyclopeptide in self-assembled monolayers on gold surfaces shows efficient through-bond electron transfer from the ferrocenes to the electrode surface via the peptidic backbone, as well as markedly improved sensing properties toward anionic species in org. electrolyte, as compared to those obsd. in homogeneous soln. [on SciFinder(R)]