Département de chimie moléculaire

Aptamer based electrochemical sensors are now developed for the detection of a wide variety of analytes including ions, low molecular weight molecules, proteins and living cells. An aptamer-based sensor is an analytical device whose the bio-sensing element (i.e. the aptamer) is immobilized on a transducer surface. Aptasensors have attracted great attention because of their high selectivity, sensitivity and stability, they could be miniaturized and are of low production cost and offer extraordinary flexibility in the design of their assemblies. This review will emphasize recent developments of aptasensors using aptamers able to adopt the particular G-quadruplex (G4) conformations, which are secondary DNA structures formed from guanine-rich sequences. Indeed, G4 exhibits notable recognition properties inherent to their particular structuration.