Reactions of In Situ Generated N-Boc Nitrones with Aromatic and Heteroaromatic Grignard Reagents: Application to the Synthesis of Zileuton.
A new class of $\alpha$-arom. N-hydroxylamines has been prepd. by reaction of tert-Bu (phenylsulfonyl)alkyl-N-hydroxycarbamates with arom. and heteroarom. Grignard reagents. Reactions proceed via a base-assisted elimination of the phenylsulfonyl group leading to N-Boc nitrones. This methodol. has been applied to the synthesis of zileuton. [on SciFinder(R)]
Références
- Titre
- Reactions of In Situ Generated N-Boc Nitrones with Aromatic and Heteroaromatic Grignard Reagents: Application to the Synthesis of Zileuton.
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Guinchard, Xavier, and Denis Jean-Noël
- Revue
- J. Org. Chem.
- Volume
- 73
- Pagination
- 2028–2031
- ISSN
- 0022-3263
Soumis le 12 avril 2018