Reactions of In Situ Generated N-Boc Nitrones with Aromatic and Heteroaromatic Grignard Reagents: Application to the Synthesis of Zileuton.

A new class of $\alpha$-arom. N-hydroxylamines has been prepd. by reaction of tert-Bu (phenylsulfonyl)alkyl-N-hydroxycarbamates with arom. and heteroarom. Grignard reagents. Reactions proceed via a base-assisted elimination of the phenylsulfonyl group leading to N-Boc nitrones. This methodol. has been applied to the synthesis of zileuton. [on SciFinder(R)]

Références

Titre
Reactions of In Situ Generated N-Boc Nitrones with Aromatic and Heteroaromatic Grignard Reagents: Application to the Synthesis of Zileuton.
Type de publication
Article de revue
Année de publication
2008
Revue
J. Org. Chem.
Volume
73
Pagination
2028–2031
ISSN
0022-3263
Soumis le 12 avril 2018