Randomized Combinatorial Library of Hetero-glyco-clusters (hGC).

We have developed an expedient strategy for generation and purifn. of randomized mixt.-based hGC library displaying up to four carbohydrates and amino acids. To emphasize the potential applications of this new generation of glycoclusters and demonstrate the proof of this concept, we have explored by affinity chromatog. the contact surface of ConA with a mannose-based library. We have thus selected ligands and shown by SPR that tyrosine influences the binding. This approach might find broad interest in glycomic or proteomic research, going from the discovery of new selective ligands or glycomimetics, to the profiling of the glyco-patterns of proteins. [on SciFinder(R)]

Références

Titre
Randomized Combinatorial Library of Hetero-glyco-clusters (hGC).
Type de publication
Article de revue
Année de publication
2008
Revue
J. Comb. Chem.
Volume
10
Pagination
368–371
ISSN
1520-4766
Soumis le 12 avril 2018