Proflavine derivatives as fluorescent imaging agents of amyloid deposits.
A series of proflavine derivs. for use to further image A$\beta$ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 mo old) mice hippocampus sections incubated with these derivs. revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compds. on A$\beta$40 fibril formation. This study highlights the potential of proflavine as a mol. scaffold for designing new A$\beta$ imaging agents, its native fluorescence allowing in vitro neuropathol. staining in AD damaged brain sections. [on SciFinder(R)]
Références
- Titre
- Proflavine derivatives as fluorescent imaging agents of amyloid deposits.
- Type de publication
- Article de revue
- Année de publication
- 2011
- Auteurs
- Garin, Dominique, Oukhatar Fatima, Mahon Andrew B., Try Andrew C., Dubois-Dauphin Michel, Laferla Frank M., Demeunynck Martine, Sallanon Marcelle Moulin, and Chierici Sabine
- Revue
- Bioorg. Med. Chem. Lett.
- Volume
- 21
- Pagination
- 2203–2206
- ISSN
- 0960-894X
Soumis le 12 avril 2018