Proflavine derivatives as fluorescent imaging agents of amyloid deposits.

A series of proflavine derivs. for use to further image A$\beta$ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 mo old) mice hippocampus sections incubated with these derivs. revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compds. on A$\beta$40 fibril formation. This study highlights the potential of proflavine as a mol. scaffold for designing new A$\beta$ imaging agents, its native fluorescence allowing in vitro neuropathol. staining in AD damaged brain sections. [on SciFinder(R)]

Références

Titre
Proflavine derivatives as fluorescent imaging agents of amyloid deposits.
Type de publication
Article de revue
Année de publication
2011
Revue
Bioorg. Med. Chem. Lett.
Volume
21
Pagination
2203–2206
ISSN
0960-894X
Soumis le 12 avril 2018