Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations.

An unambiguous picture of the interaction between the inhibitor kojic acid (KA) and a model of the dicopper active site of tyrosinase (Ty) is reported. The obsd. binding mode probed on bacterial enzyme is confirmed and further refined by QM/MM calcns. [on SciFinder(R)]

Références

Titre
Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations.
Type de publication
Article de revue
Année de publication
2014
Revue
Chem. Commun. (Cambridge, United Kingdom)
Volume
50
Pagination
308–310
ISSN
1359-7345
Soumis le 12 avril 2018