Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.

A water-sol. template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramol. folds alone in soln. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent. [on SciFinder(R)]

Références

Titre
Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.
Type de publication
Article de revue
Année de publication
2016
Revue
Chem. - A Eur. J.
Volume
22
Pagination
1760–1767
ISSN
0947-6539
Soumis le 12 avril 2018