Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.
A water-sol. template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramol. folds alone in soln. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent. [on SciFinder(R)]
Références
- Titre
- Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.
- Type de publication
- Article de revue
- Année de publication
- 2016
- Auteurs
- Flack, Theodore, Constantin Thibaut, Penasse Sylvain, Dejeu Jérôme, Gennaro Béatrice, Jourdan Muriel, Laguerre Aurelien, Pirrotta Marc, Monchaud David, Spinelli Nicolas, and Defrancq Eric
- Revue
- Chem. - A Eur. J.
- Volume
- 22
- Pagination
- 1760–1767
- ISSN
- 0947-6539
Soumis le 12 avril 2018