Département de chimie moléculaire

Polyhydroxylated quinolizidines, e.g. I, bearing a hydroxymethyl group at the ring junction were synthesized from a readily available L-sorbose-derived keto-nitrone. Evaluated as glycoside hydrolase inhibitors, these quinolizidines revealed to be potent and selective alpha-glucosidase inhibitors. Quinolizidine I is the first quinolizidine-scaffolded iminosugar exhibiting nanomolar inhibition of a glycoenzyme.