The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH.

The high-valent manganese-oxo species of Mn-TMPyP4 porphyrin interacts in the minor grooves of AT-rich regions of DNA and mediates hydroxylation of C-H bonds of deoxyribose leading to DNA break. The reaction was obsd. at different pHs. The hydroxylation was not efficient at low pH (pH 6) while it worked well at higher pH (pH 8). Deprotonation of the coordinated water mol., trans to the manganese-oxo entity, into a hydroxide anion drives high-valent manganese-oxo porphyrin toward hydroxylation at pH {\textgreater} 7. [on SciFinder(R)]

Références

Titre
The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH.
Type de publication
Article de revue
Année de publication
2017
Revue
Dalt. Trans.
Volume
46
Pagination
12088–12094
ISSN
1477-9226
Soumis le 12 avril 2018