Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro.
See you later amyloid $\beta$: A screen of a small library of oxime oligomers with an HTS fluorescence assay for amyloid fibril inhibition and subsequent investigation by at. force microscopy revealed two new micromolar inhibitors of amyloid fibril formation. These new inhibitors have IC50 values in the 10 $μ$M range. [on SciFinder(R)]
Références
- Titre
- Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro.
- Type de publication
- Article de revue
- Année de publication
- 2009
- Auteurs
- Dolphin, Gunnar T., Renaudet Olivier, Ouberai Myriam, Dumy Pascal, Garcia Julian, and Reymond Jean-Louis.
- Revue
- ChemBioChem
- Volume
- 10
- Pagination
- 1325–1329
- ISSN
- 1439-4227
Soumis le 12 avril 2018