Département de chimie moléculaire

The prepn. of 17- and 18-membered cyclic hexapeptides from N-hydroxy tripeptides building blocks is described. Introduction of an unsatd. chain on the hydroxamate oxygen followed by fragment coupling leads to N,N'-dialkenoxy hexapeptides that are efficiently cyclized through a ring-closing metathesis reaction. The length of the alkene chains allows the modulation of the ring size. [on SciFinder(R)]