Peptide cyclization via ring-closing metathesis: the N-alkenoxy peptide approach.
The prepn. of 17- and 18-membered cyclic hexapeptides from N-hydroxy tripeptides building blocks is described. Introduction of an unsatd. chain on the hydroxamate oxygen followed by fragment coupling leads to N,N'-dialkenoxy hexapeptides that are efficiently cyclized through a ring-closing metathesis reaction. The length of the alkene chains allows the modulation of the ring size. [on SciFinder(R)]
Références
- Titre
- Peptide cyclization via ring-closing metathesis: the N-alkenoxy peptide approach.
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Lawrence, James, Jourdan Muriel, Vallee Yannick., and Blandin Véronique
- Revue
- Org. Biomol. Chem.
- Volume
- 6
- Pagination
- 4575–4581
- ISSN
- 1477-0520
- DOI
- 10.1039/b812611a
Soumis le 12 avril 2018