Peptide cyclization via ring-closing metathesis: the N-alkenoxy peptide approach.

The prepn. of 17- and 18-membered cyclic hexapeptides from N-hydroxy tripeptides building blocks is described. Introduction of an unsatd. chain on the hydroxamate oxygen followed by fragment coupling leads to N,N'-dialkenoxy hexapeptides that are efficiently cyclized through a ring-closing metathesis reaction. The length of the alkene chains allows the modulation of the ring size. [on SciFinder(R)]

Références

Titre
Peptide cyclization via ring-closing metathesis: the N-alkenoxy peptide approach.
Type de publication
Article de revue
Année de publication
2008
Revue
Org. Biomol. Chem.
Volume
6
Pagination
4575–4581
ISSN
1477-0520
Soumis le 12 avril 2018