Département de chimie moléculaire

A new efficient multi-catalytic pseudo four-component strategy combining an aldehyde, a beta-keto-acid and two equivalents of a fluorinating agent has been designed. Thanks to the combined effects of a secondary amine as organocatalyst and a copper catalyst, highly volatile gem-difluorinated intermediates can be produced and trapped in situ by a chemo-compatible decarboxylative aldolization providing a rapid access to original gem-difluorinated beta-aldol building blocks.