Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA.
Oligonucleotide-selenium conjugate was designed and synthesized and its sequence-specific crosslinking ability was investigated. The selenide derivs. can generate covalent interstrand crosslinking with its complementary strand through the formation of o-QM intermediate induced by periodate oxidn. A crosslinking reaction yield of up to 50{%} was obtained. Hydroxyl radical footprinting expt. revealed that the quinone appendage specifically alkylated the cytosine base extending the duplex formed between the conjugate and the target strand. [on SciFinder(R)]
Références
- Titre
- Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA.
- Type de publication
- Article de revue
- Année de publication
- 2010
- Auteurs
- Du, Yuhao, Weng Xiaocheng, Huang Jing, Zhang Dan, Ma Heng, Chen Dong, Zhou Xiang, and Constant Jean-François
- Revue
- Bioorg. Med. Chem.
- Volume
- 18
- Pagination
- 4149–4153
- ISSN
- 0968-0896
Soumis le 12 avril 2018