Département de chimie moléculaire

We report herein the synthesis and characterization of the novel water-sol. peptidic scaffold-oligonucleotide conjugate 1 that mimics the parallel-stranded conformation of G quadruplex. We demonstrate that the use of the scaffold allows the precise control of the conformation of the quadruplex and dramatically increases the stability of the motif–all the more so as the formation of the quadruplex motif is possible even without the addn. of any monovalent cations, such as K+. We also show that mimic 1 can be used for surface functionalization, and this permits the study of the mol. interaction with G-quadruplex ligands by using surface plasmon resonance (SPR). [on SciFinder(R)]