Noncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors.

A highly efficient surface plasmon resonance (SPR) immunosensor is described using a functionalized single graphene layer on a thin gold film. The aim of this approach was two-fold: first, to amplify the SPR signal by growing graphene through chem. vapor deposition and, second, to control the immobilization of biotinylated cholera toxin antigen on copper coordinated nitrilotriacetic acid (NTA) using graphene as an ultrathin layer. The NTA groups were attached to graphene via pyrene derivs. implying $π$-$π$ interactions. With this setup, an immunosensor for the specific antibody anticholera toxin with a detection limit of 4 pg mL-1 was obtained. In parallel, NTA polypyrrole films of different thicknesses were electrogenerated on the gold sensing platform where the optimal electropolymn. conditions were detd. For this optimized polypyrrole-NTA setup, the simple presence of a graphene layer between the gold and polymer film led to a significant increase of the SPR signal. [on SciFinder(R)]

Références

Titre
Noncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors.
Type de publication
Article de revue
Année de publication
2015
Revue
J. Am. Chem. Soc.
Volume
137
Pagination
2800–2803
ISSN
0002-7863
Soumis le 12 avril 2018