Noncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors.
A highly efficient surface plasmon resonance (SPR) immunosensor is described using a functionalized single graphene layer on a thin gold film. The aim of this approach was two-fold: first, to amplify the SPR signal by growing graphene through chem. vapor deposition and, second, to control the immobilization of biotinylated cholera toxin antigen on copper coordinated nitrilotriacetic acid (NTA) using graphene as an ultrathin layer. The NTA groups were attached to graphene via pyrene derivs. implying $π$-$π$ interactions. With this setup, an immunosensor for the specific antibody anticholera toxin with a detection limit of 4 pg mL-1 was obtained. In parallel, NTA polypyrrole films of different thicknesses were electrogenerated on the gold sensing platform where the optimal electropolymn. conditions were detd. For this optimized polypyrrole-NTA setup, the simple presence of a graphene layer between the gold and polymer film led to a significant increase of the SPR signal. [on SciFinder(R)]
Références
- Titre
- Noncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors.
- Type de publication
- Article de revue
- Année de publication
- 2015
- Auteurs
- Singh, Meenakshi, Holzinger Michael, Tabrizian Maryam, Winters Sinead, Berner Nina C., Cosnier Serge, and Duesberg Georg S.
- Revue
- J. Am. Chem. Soc.
- Volume
- 137
- Pagination
- 2800–2803
- ISSN
- 0002-7863
Soumis le 12 avril 2018