Non-invasive tools for detecting vulnerable atherosclerotic plaques.
The present invention relates to a polypeptide comprising or constituted of the sequence RILAR (SEQ ID NO: 3), the use thereof in imaging methods, in diagnostic or prognostic methods and for use as a medicament. Mice with focal atherosclerotic lesions were injected with 99mTc-labeled HGRANLRILARY and subjected to SPECT imaging. There was higher tracer activity in the atherosclerotic lesion than in the contralateral vessel, resulting in a significantly higher mean tracer activity. [on SciFinder(R)]
Références
- Titre
- Non-invasive tools for detecting vulnerable atherosclerotic plaques.
- Type de publication
- Brevet
- Année de publication
- 2010
- Auteurs
- Fagret, Daniel, Ghezzi Catherine, Dumy Pascal, Riou Laurent, and Boturyn Didier
- Patent Number
- WO 2010079156 A1
Soumis le 23 mai 2018