New Solid Support for the Synthesis of 3'-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation.
A novel solid support 1 was synthesized to incorporate glyoxylic aldehyde functionality at the oligonucleotide 3'-terminus. 6-Mer and 11-mer oligonucleotide sequences contg. 3'-glyoxylic aldehyde functionality were prepd. by using this support. These modified oligonucleotides were coupled to reporters contg. an aminooxy group to prep. oligonucleotide 3'-conjugates through glyoxylic oxime bond formation. The hydrolytic stability of a glyoxylic oxime linkage was also investigated. [on SciFinder(R)]
Références
- Titre
- New Solid Support for the Synthesis of 3'-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation.
- Type de publication
- Article de revue
- Année de publication
- 2007
- Auteurs
- Spinelli, Nicolas, Edupuganti Om Prakash, Defrancq Eric, and Dumy Pascal
- Revue
- Org. Lett.
- Volume
- 9
- Pagination
- 219–222
- ISSN
- 1523-7060
Soumis le 12 avril 2018