New Ruthenium-Based Probes for Selective G-Quadruplex Targeting.

Telomeric regions contg. G-quadruplex (G4) structures play a pivotal role in the development of cancers. The development of specific binders for G4s is thus of great interest in order to gain a deeper understanding of the role of these structures, and to ultimately develop new anticancer drug candidates. For several years, RuII complexes have been studied as efficient probes for DNA. Interest in these complexes stems mainly from the tunability of their structures and properties, and the possibility of using light excitation as a tool to probe their environment or to selectively trigger their reaction with a biol. target. Herein, we report on the synthesis and thorough study of new RuII complexes based on a novel dipyrazino[2,3-a:2',3'-h]phenazine ligand (dph), obtained through a Chichibabin-like reaction. Luminescence expts., surface plasmon resonance (SPR), and computational studies have demonstrated that these complexes behave as selective probes for G-quadruplex structures. [on SciFinder(R)]

Références

Titre
New Ruthenium-Based Probes for Selective G-Quadruplex Targeting.
Type de publication
Article de revue
Année de publication
2017
Revue
Chem. - A Eur. J.
Volume
23
Pagination
11872–11880
ISSN
0947-6539
Soumis le 12 avril 2018