New route to natural camptothecin through isomunchnone cycloaddition.
A novel approach to camptothecin (I) is described employing [3+2] cycloaddn. of isomunchnone intermediate II, a Suzuki coupling, and a Shibasaki enantioselective cyanosilylation. The synthesis requires 12 steps and proceeds in {\textgreater}15{%} overall yield. [on SciFinder(R)]
Références
- Titre
- New route to natural camptothecin through isomunchnone cycloaddition.
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Kanazawa, Alice, Muniz Mauro N., Baumlova Barbora, Ljungdahl Natalie, and Greene Andrew E.
- Revue
- Synlett
- Pagination
- 2275–2278
- ISSN
- 0936-5214
Soumis le 12 avril 2018