New route to natural camptothecin through isomunchnone cycloaddition.

A novel approach to camptothecin (I) is described employing [3+2] cycloaddn. of isomunchnone intermediate II, a Suzuki coupling, and a Shibasaki enantioselective cyanosilylation. The synthesis requires 12 steps and proceeds in {\textgreater}15{%} overall yield. [on SciFinder(R)]

Références

Titre
New route to natural camptothecin through isomunchnone cycloaddition.
Type de publication
Article de revue
Année de publication
2008
Revue
Synlett
Pagination
2275–2278
ISSN
0936-5214
Soumis le 12 avril 2018