Département de chimie moléculaire

A 15 625-membered peptide dendrimer combinatorial library was acylated with an $\alpha$-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 (Fuc-$\alpha$-CH2CO-Lys-Pro-Leu)4(Lys-Phe-Lys-Ile)2Lys-His-Ile-NH2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 $μ$M) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 $μ$M). [on SciFinder(R)]