Département de chimie moléculaire

We investigated how near-IR imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clin. veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clin. grade imaging system. All tumors were labeled by the tracer and had an overall tumor-to-healthy tissue ratio of 14 ± 1 during surgery. No false negatives were found, and the percentage of tumor cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1 yr after the beginning of the study. [on SciFinder(R)]