Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-$\alpha$vss3 integrin molecular probe.
We investigated how near-IR imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clin. veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clin. grade imaging system. All tumors were labeled by the tracer and had an overall tumor-to-healthy tissue ratio of 14 ± 1 during surgery. No false negatives were found, and the percentage of tumor cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1 yr after the beginning of the study. [on SciFinder(R)]
Références
- Titre
- Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-$\alpha$vss3 integrin molecular probe.
- Type de publication
- Article de revue
- Année de publication
- 2013
- Auteurs
- Wenk, Christiane H. F., Ponce Frederique, Guillermet Stephanie, Tenaud Corinne, Boturyn Didier, Dumy Pascal, Watrelot-Virieux Dorothee, Carozzo Claude, Josserand Veronique, and Coll Jean-Luc.
- Revue
- Cancer Lett. (New York, NY, United States)
- Volume
- 334
- Pagination
- 188–195
- ISSN
- 0304-3835
Soumis le 12 avril 2018