Département de chimie moléculaire

Detecting heparin: We report a new fluorescent approach to the detection and quantification of the biol. relevant mol. heparin. We designed and prepd. a cyclic peptide that is able to catalyze the hydrolysis of a fluorogenic anionic ester (green) under low-concn. conditions. Then we demonstrated that the inhibition of this artificial enzyme (gray) by heparin (red) allows its fluorescent sensing with a remarkable sensitivity of 13 nM. [on SciFinder(R)]