Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.

Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topol., offering new opportunities in multitargeted drug design.

Références

Titre
Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.
Type de publication
Article de revue
Année de publication
2019
Revue
Chem. Commun. (Cambridge, U. K.)
Volume
55
Pagination
12845–12848
ISSN
1359-7345
Soumis le 15 janvier 2020